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Magic™ Membrane Protein Human ASGR1 (Asialoglycoprotein receptor 1) Expressed in NS0 for Antibody Discovery, Partial (62-291aa) (CAT#: MPX0425K)

Datasheet
This product is a 27.6 kDa Human ASGR1 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ASGR1
  • Protein Length
  • Partial (62-291aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 27.6 kDa
  • TMD
  • 1
  • Sequence
  • QNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGR
    KMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSE
    RTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKF
    VQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLG
    GGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • 9xHis tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • ASGR1
  • Full Name
  • Asialoglycoprotein receptor 1
  • Introduction
  • This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Alternative Names
  • ASGR1; HL-1; ASGPR; ASGPR1; CLEC4H1; C-type lectin domain family 4 member H1; hepatic lectin H1; Asialoglycoprotein receptor 1

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