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Magic™ Membrane Protein Human COMT (Catechol-O-methyltransferase) Expressed in E.coli for Antibody Discovery, Partial (52-271aa) (CAT#: MPX0215K)

Datasheet
This product is a 25 kDa Human COMT membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • COMT
  • Protein Length
  • Partial (52-271aa)
  • Protein Class
  • Transferase
  • Molecular Weight
  • 25 kDa
  • TMD
  • 1
  • Sequence
  • GDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIV
    DAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQ
    RMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPD
    TLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEY
    REVVDGLEKAIYKGPGSEAGP

Product Description

  • Expression Systems
  • E.coli
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Supplied as a 0.2 μm filtered solution in Tris, NaCl, Glycerol and TCEP.

Target

  • Target Protein
  • COMT
  • Full Name
  • Catechol-O-methyltransferase
  • Introduction
  • Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
  • Alternative Names
  • COMT; HEL-S-98n; catechol O-methyltransferase; epididymis secretory sperm binding protein Li 98n; testicular tissue protein Li 42; Catechol-O-methyltransferase

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