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Magic™ Membrane Protein Human DSC3 (Desmocollin 3) Expressed in NS0 for Antibody Discovery, Partial (136-690aa) (CAT#: MPX0173K)

Datasheet
This product is a 62.9 kDa Human DSC3 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DSC3
  • Protein Length
  • Partial (136-690aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 62.9 kDa
  • TMD
  • 1
  • Sequence
  • RWAPIPCSMQENSLG
    PFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRP
    VDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNF
    EVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPS
    TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSND
    NAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNE
    NGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRV
    TALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPEN
    RNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVL
    AIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPD
    EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPI
    TVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGK

Product Description

  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >85%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • DSC3
  • Full Name
  • Desmocollin 3
  • Introduction
  • The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.
  • Alternative Names
  • DSC3; DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP; desmocollin-3; cadherin family member 3; desmocollin-4; Desmocollin 3

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