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Magic™ Membrane Protein Human KIDINS220 (Kinase D interacting substrate 220) Full Length (CAT#: MPC1406K) Made to Order

This product is a 196.5 kDa Human KIDINS220 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KIDINS220
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 196.5 kDa
  • TMD
  • 4
  • Sequence
  • MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGN
    LEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHR
    DMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHA
    DIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG
    ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTE
    IVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQ
    DNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEV
    VELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRP
    NKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYSSALADI
    LSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWL
    IVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLALLYIFFIVIYFGGRRE
    GESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFT
    DYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFKTEDTQGKKK
    WKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVV
    GLAFVLNCRTWWQVLDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVE
    LMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPF
    IAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLS
    NARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGSKTALNR
    RDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTG
    RLLRANQISFNWDRLASWINLTEQWPYRTSWLILYLEETEGIPDQMTLKT
    IYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVKVFLPC
    TVNLDPKLREIIADVRAAREQISIGGLAYPPLPLHEGPPRAPSGYSQPPS
    VCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRPFFAPYLYTPRY
    YPGGSQHLISRPSVKTSLPRDQNNGLEVIKEDAAEGLSSPTDSSRGSGPA
    PGPVVLLNSLNVDAVCEKLKQIEGLDQSMLPQYCTTIKKANINGRVLAQC
    NIDELKKEMNMNFGDWHLFRSTVLEMRNAESHVVPEDPRFLSESSSGPAP
    HGEPARRASHNELPHTELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSW
    QSQTRRTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGG
    PGSTTISGRSSPHSTYYMGQSSSGGSIHSNLEQEKGKDSEPKPDDGRKSF
    LMKRGDVIDYSSSGVSTNDASPLDPITEEDEKSDQSGSKLLPGKKSSERS
    SLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDRKAEGKVE
    RVPKSPEHSAEPIRTFIKAKEYLSDALLDKKDSSDSGVRSSESSPNHSLH
    NEVADDSQLEKANLIELEDDSHSGKRGIPHSLSGLQDPIIARMSICSEDK
    KSPSECSLIASSPEENWPACQKAYNLNRTPSTVTLNNNSAPANRANQNFD
    EMEGIRETSQVILRPSSSPNPTTIQNENLKSMTHKRSQRSSYTRLSKDPP
    ELHAAASSESTGFGEERESIL

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • KIDINS220
  • Full Name
  • Kinase D interacting substrate 220
  • Introduction
  • This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • KIDINS220; ARMS; SINO; kinase D-interacting substrate of 220 kDa; ankyrin repeat-rich membrane-spanning protein; kinase D-interacting substrate 220kDa; Kinase D interacting substrate 220

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