Magic™ Membrane Protein Human KIR3DL3 (Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3) Full Length (CAT#: MPC2993K) Made to Order

Name: Magic™ Membrane Protein Human KIR3DL3 (Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3) Full Length
SKU: MPC2993K
Rating: 5 (1 reviews)

Datasheet

This product is a made-to-order Human KIR3DL3 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
KIR3DL3

Protein Length
Full length

Protein Class
Receptor

Sequence
MSLMVVSMACVGFFLLEGPWPHVGGQDKPFLSAWPGTVVSEGQHVTLQCR
SRLGFNEFSLSKEDGMPVPELYNRIFRNSFLMGPVTPAHAGTYRCCSSHP
HSPTGWSAPSNPVVIMVTGVHRKPSLLAHPGPLVKSGETVILQCWSDVRF
ERFLLHREGITEDPLRLVGQLHDAGSQVNYSMGPMTPALAGTYRCFGSVT
HLPYELSAPSDPLDIVVVGLYGKPSLSAQPGPTVQAGENVTLSCSSRSLF
DIYHLSREAEAGELRLTAVLRVNGTFQANFPLGPVTHGGNYRCFGSFRAL
PHAWSDPSDPLPVSVTGNSRHLHVLIGTSVVIIPFAILLFFLLHRWCANK
KNAVVMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQRKITRPSQR
PKTPPTDTSV

Product Description

Expression Systems
HEK293

Tag
Flag-StrepII or based on specific requirements

Protein Format
Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, Polymer, VLP)

Target

Target Protein
KIR3DL3

Full Name
Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.

Alternative Names
KIR3DL3; KIR44; KIRC1; CD158Z; KIR3DL7; killer cell immunoglobulin-like receptor 3DL3; CD158 antigen-like family member Z; KIR3DL3 Killer-cell Immunoglobulin-like Receptor; KIR3DL33DL3*novel_CDS_genomic_submission_1; killer cell Ig-like receptor KIR3DL7; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3; killer cell inhibitory receptor 1; killer-cell immunoglobulin-like receptor 3DL3; truncated killer cell immunoglobulin-like receptor 3DL3; Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

Gene ID
115653

UniProt ID
Q8N743

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