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Magic™ Membrane Protein Human PGRMC2 (Progesterone receptor membrane component 2) for Antibody Discovery (CAT#: MP1228J)

This product is a 26 kDa Human PGRMC2 membrane protein expressed in HEK293T. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PGRMC2
  • Protein Length
  • Full-length
  • Protein Class
  • Druggable Genome, Nuclear Hormone Receptor, Transmembrane
  • Molecular Weight
  • 26 kDa
  • TMD
  • 1
  • Sequence
  • MAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAALALLTGGGEMLLNVALVALVLLGAYR
    LWVRWGRRGLGAGAGAGEESPATSLPRMKKRDFSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPA
    GPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEY
    TDEEDTKDHNKQD

Product Description

  • Expression Systems
  • HEK293T
  • Tag
  • C-Myc/DDK
  • Purification
  • Anti-DDK affinity column followed by conventional chromatography steps
  • Purity
  • > 80% as determined by SDS-PAGE and Coomassie blue staining
  • Buffer
  • 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Target

  • Target Protein
  • PGRMC2
  • Full Name
  • Progesterone receptor membrane component 2
  • Introduction
  • Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus. Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1.
  • Alternative Names
  • DG6; PMBP; steroid receptor protein DG6; progesterone membrane binding protein

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