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Magic™ Membrane Protein Human PKD1 (Polycystin 1, transient receptor potential channel interacting) Expressed in E.coli with 6xHis tag at the N-terminus, 6xHis tag at the C-terminus for Antibody Discovery, Partial (25-636aa) (CAT#: MPX4139K)

Datasheet
This product is a 66.5 kDa Human PKD1 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PKD1
  • Protein Length
  • Partial (25-636aa)
  • Protein Class
  • Transporter
  • Molecular Weight
  • 66.5 kDa
  • TMD
  • 11
  • Sequence
  • GPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPHGPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRSLDVWIGFSTVQGVEVGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNRTQL

Product Description

  • Expression Systems
  • E.coli
  • Tag
  • 6xHis tag at the N-terminus, 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Purity
  • >85% as determined by SDS-PAGE.
  • Buffer
  • Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

  • Target Protein
  • PKD1
  • Full Name
  • Polycystin 1, transient receptor potential channel interacting
  • Introduction
  • This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.
  • Alternative Names
  • PBP; PC1; Pc-1; TRPP1; polycystin-1; autosomal dominant polycystic kidney disease 1 protein; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease-associated protein; transient receptor potential cation channel, subfamily P, member 1; PKD1; Polycystin 1, transient receptor potential channel interacting

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