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Magic™ Membrane Protein Human SLC8A1 (Solute carrier family 8 member A1) Full Length (CAT#: MPC0914K) Made to Order

Datasheet
This product is a 108.5 kDa Human SLC8A1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SLC8A1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 108.5 kDa
  • TMD
  • 10
  • Sequence
  • MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECT
    GSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFM
    SSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEIL
    LSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKH
    LRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAW
    VADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
    ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELAN
    YQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEV
    TENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGT
    ANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKV
    SSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVS
    ESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
    EIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTI
    TGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAE
    MGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIE
    AITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNG
    WACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDT
    FASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF
    KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCL
    FVLLWLLYIFFSSLEAYCHIKGF

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • SLC8A1
  • Full Name
  • Solute carrier family 8 member A1
  • Introduction
  • In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.
  • Alternative Names
  • NCX1; sodium/calcium exchanger 1; Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; solute carrier family 8 (sodium/calcium exchanger), member 1; solute carrier family 8 member 1; SLC8A1; Solute carrier family 8 member A1

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