Close
Close

Magic™ Membrane Protein Human SORCS3 (Sortilin related VPS10 domain containing receptor 3) Full Length (CAT#: MPC1474K) Made to Order

Datasheet
This product is a 135.7 kDa Human SORCS3 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SORCS3
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 135.7 kDa
  • TMD
  • 1
  • Sequence
  • MEAARTERPAGRPGAPLVRTGLLLLSTWVLAGAEITWDATGGPGRPAAPA
    SRPPALSPLSPRAVASQWPEELASARRAAVLGRRAGPELLPQQGGGRGGE
    MQVEAGGTSPAGERRGRGIPAPAKLGGARRSRRAQPPITQERGDAWATAP
    ADGSRGSRPLAKGSREEVKAPRAGGSAAEDLRLPSTSFALTGDSAHNQAM
    VHWSGHNSSVILILTKLYDFNLGSVTESSLWRSTDYGTTYEKLNDKVGLK
    TVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGATYQKYRLTFYIQSL
    LFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVAGLDK
    EADLVHMEVRTTDGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEY
    IFIQVTTSGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAV
    QEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKG
    IFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHL
    HLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNT
    WRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTS
    VPLFVDGALVEAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKED
    YQTWHLLNQGEPCVMGERKIFKKRKPGAQCALGRDHSGSVVSEPCVCANW
    DFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNN
    CTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEG
    DLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLG
    SDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWW
    FGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNALIQDTKEIAVHEYF
    QSQLLSFSPNLDYHNPDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFP
    GLPTSAELFILPPKNLTERRKGNEGDLEQIVETLFNALNQNLVQFELKPG
    VQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKI
    PWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRV
    IGGIATIANSESTKEIPNCTSV

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • SORCS3
  • Full Name
  • Sortilin related VPS10 domain containing receptor 3
  • Introduction
  • This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing.
  • Alternative Names
  • SORCS3; SORCS; VPS10 domain-containing receptor SorCS3; VPS10 domain receptor protein SORCS 3 (SORCS3); Sortilin related VPS10 domain containing receptor 3

Customer reviews and Q&As    

Related Products
Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2024 Creative Biolabs. | Contact Us