NAA and Epilepsy
In recent years, there has been increasing interest in the important role of natural autoantibodies (NAAs) in the pathogenesis and treatment of epilepsy. As a leading service provider in the field of NAA detection and analysis, with an experienced team and advanced technology platform, Creative Biolabs provides global customers with high-quality NAA detection and analysis services to accelerate your projects.
Introduction of Epilepsy
Epilepsy, the most common neurological disorder, is defined as a temporary condition characterized by two or more unprovoked seizures caused by abnormally excessive or synchronized neuronal activity in the brain. Epilepsy is a chronic and serious neurological disease, which seriously affects the quality of life of patients and brings economic burden to society. Although epilepsy can be successfully treated in most cases, treatment outcomes are influenced by a variety of factors. In recent years, great progress has been made in the study of the pathological mechanism and influencing factors of this disease. Furthermore, neuroimaging plays a crucial role in the diagnosis and treatment of epilepsy patients.
Pathophysiology of Epilepsy
The pathological mechanism of epileptic seizures is closely related to the excessive synchronization and sustained discharge of neurons. All epilepsy is characterized by a persistent increase in neuronal excitability. Abnormal cellular discharge may be associated with a variety of pathogenic factors, such as hypoxia, trauma, infection, and metabolic disturbances. It is involved in multiple processes such as alterations in extracellular ion homeostasis, energy metabolism, receptor function, and transmitter uptake.
Fig.1 Basic cascade events of the pathophysiology of epilepsy.1
Natural Autoantibodies in Epilepsy
The etiology of epilepsy is still unclear, but seizures can be caused by a variety of factors, such as environmental and genetic factors. Recently, autoantibodies against neuronal targets have attracted a lot of attention, including the voltage-gated potassium channel complex (VGKC-complex), glutamate decarboxylase (GAD), N-methyl-D-aspartate receptor (NMDAR) and glycine receptor (GLYR). Research suggests that these molecules may be associated with the etiology of limbic encephalitis and epilepsy in idiopathic cases.
NAA-related Services in Creative Biolabs
- NAA Services for Anti-VGKC (Kv1.4)
- NAA Services for Anti-glutamic Acid Decarboxylase (GAD)
- NAA Services for Anti-GluR3 Antibody
- NAA Services for Anti-phospholipid Antibodies
Related Products in Creative Biolabs
| Target | Product name | Cat.No |
|---|---|---|
| GAD autoantibodies | Mouse GAD Autoantibody (IgG) ELISA Kit | NAK-001 |
| dsDNA autoantibodies | Human dsDNA Autoantibody (IgG) ELISA kit | NAK-035 |
| dsDNA autoantibodies | Human dsDNA Autoantibody (IgG&IgM&IgA) ELISA kit | NAK-036 |
NAA plays an increasingly important role in the pathological research and treatment of epilepsy. As experts in the research field, Creative Biolabs specializes in providing a wide variety of NAA detection and analysis services to customers around the world. Please contact us for details.
Reference
- Hastuti, Sri, et al. "hUMSC vs. hUMSC–Exosome: Which One Is Better for Epilepsy?." Pharmaceuticals 15.10 (2022): 1247.
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