NAA Services for Anti-Centromere Antibody (ACA)
Anti-centromere antibody (ACA) is a type of natural autoantibody (NAA) directly reacting with the centromere, which has been demonstrated to be related to several autoimmune diseases. Based on over a decade of experience and first-in-class technologies in NAA research, Creative Biolabs has successfully developed a series of diversified NAA platforms and several effective strategies to provide the best and perfect services for our worldwide customers. At present, we are able to provide a full range of anti-centromere antibody (ACA) marker services for diseases diagnosis and therapeutic monitoring. Our professional team is optimized to help you get a milestone development in your NAA project.
Background of Anti-centromere Antibody (ACA)
The centromere is a specialized DNA sequence of a chromosome that links a pair of sister chromatids. It plays an essential role in proper chromosome segregation during mitosis and meiosis in eukaryotic cells. Obviously, centromere misregulation will lead to dysfunctions and diseases. Anti-centromere antibodies (ACAs) are autoantibodies specific to centromere proteins and kinetochore function. ACAs mainly recognize three centromere proteins A, B, and C or (CENP-A, B, and C). ACA, together with anti-ACA, has been reported and confirmed associated with some autoimmune diseases, particularly was considered to be an effective auxiliary diagnostic biomarker for limited cutaneous systemic sclerosis. In addition, ACAs also can be detected in patients with primary biliary cirrhosis, Sjögren's syndrome, and other diseases.
The Role of Anti-centromere Antibody (ACA) in Sjögren's Syndrome (SS)
Sjögren's syndrome (SS) is a chronic systemic autoimmune disorder characterized by lachrymal and salivary gland dysfunction presenting as dry mouth and dry eyes. SS is one of the most common autoimmune that mainly affecting elder females accompanying other immune system disorders, such as rheumatoid arthritis and systemic lupus erythematosus. Although the pathogenesis of SS still remains unclear, evidence showed that autoreactive lymphocytes and autoantibodies directed against organ and non-organ specific autoantigens made a great contribution to this pathogenic process. Anti-Ro/SSA and anti-La/SSB are main autoantibodies confirmed by researches. Recent studies indicated that ACAs, especially anti-CENP-H antibodies are closely associated with SS, which can be developed as novel serological biomarkers for SS diagnosis.
Fig.1 The pathogenetic mechanisms at the basis of Sjogren syndrome.1
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For anti-centromere antibody and other NAAs researches, just contact us and communicate with us for more information. Our services at Creative Biolabs can cover every step of your project, from NAA detection, NAA profiling, to NAA epitope mapping. Chose us and fulfill your glycoprotein project.
Reference:
- Kelly, Anzola Luz, et al. "Sjögren Syndrome: New Insights in the Pathogenesis and Role of Nuclear Medicine." Journal of Clinical Medicine 11.17 (2022): 5227.
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