NAA Services for Anti-Denatured DNA Antibodies
With integrated antibody analysis and design techniques, Creative Biolabs establishes a comprehensive NAA (natural autoantibodies) detection service platform to provide either individual service modules or fully comprehensive service. We tailor services to develop high-quality NAA services on multiple hot diagnostic, against a variety of disease targets, with low cross-reactivity, for the development of immunology methods to meet the needs of our valued NAA clients.
Background of Anti-denatured DNA Antibodies
Anti-denatured DNA antibodies are a group of anti-nuclear antibodies (ANA) against denatured DNA strands such as double-stranded DNA (dsDNA) and single-stranded DNA (ssDNA). In 1957, they were found firstly in patients with SLE. There is a great deal of evidence suggests that the extracellular DNA is one cause of an immune response against dsDNA, and dead or dying cells are one major source of this extracellular DNA. Anti-denatured DNA antibodies can also be induced through infection via a mechanism known as molecular mimicry. The test of anti-denatured DNA antibodies is always using blood tests such as Enzyme-Linked Immunosorbent Assay (ELISA) and immunofluorescence (IF) in diagnostic laboratories. They are highly diagnostic of systemic lupus erythematosus (SLE) and are involved in the pathogenesis of lupus nephritis.
Fig.1 The release of DNA from dead and dying cells.1
The Role of Anti-denatured DNA Antibodies in AIDS
Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is an immune disease caused by infection with the human immunodeficiency virus (HIV). The increased incidence of HIV infection is demonstrated to be related to autoantibodies. The presence of anti-denatured DNA autoantibodies is significantly associated with lower CD4⁺ lymphocyte counts and increased mortality, which indicates a prognostic significance to detect autoantibodies in the context of HIV infection. Anti-denatured DNA antibodies were significantly more frequent in patients infected with HIV. Thus, the frequency and specificity of anti-denatured DNA autoantibodies in HIV-infected subjects can be regarded as a biomarker and an immunological hallmark of AIDS.
What We Can Do About NAA?
With first-rate technology platforms and prominent scientists, Creative Biolabs provides a full range of NAA services including NAA detection, NAA profiling, NAA affinity measurement, NAA epitope mapping, and paratope mapping. More importantly, a wide range of NAA products is available for your choice.
Features of Our Services
- State-of-the-art platform
- Outstanding scientists
- High efficiency and timely
- Cost-effective services
As a long-term expert in NAA services providing, Creative Biolabs owns a number of Ph.D. scientists who are proficient in NAA detection and analysis. Our professional scientists are pleased to provide the custom natural autoantibodies detection services against novel biomarkers of AIDS to diagnose AIDS disease sensitively. If you are interested in our services, please contact us for more details.
Reference
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Grabuschnig, Stefan, et al. "Putative origins of cell-free DNA in humans: a review of active and passive nucleic acid release mechanisms." International journal of molecular sciences 21.21 (2020): 8062.