NAA Services for Anti-Oxysterols Antibody
Despite the possible use of conventional different biomarkers such as metalloproteinases-2/-9 (MMP-2 and MMP-9) and Tau protein, it is necessary to continue to look for new biomarkers for early onset of the amyotrophic lateral sclerosis (ALS). As a leading provider of natural autoantibody (NAA) analysis, Creative Biolabs is committed to developing high-quality services against anti-oxysterols biomarkers.
Background of Oxysterols
Oxysterols are oxidized cholesterol derivatives with 27 carbon atoms. Oxidation can take place either on the sterol core or on the side chain. Oxysterols are important signaling molecules, capable of modulating the activity of many transcription factors in order to limit the excessive accumulation of cholesterol. Concerning neurodegenerative diseases, oxysterols that may be of interests are those present at the cerebral level, mainly 24S-hydroxycholesterol which is produced in the brain, and 27-hydroxycholesterol, which enters the brain when the permeability of the blood-brain barrier is enhanced. Given the demonstrated involvement of lipids in this pathology and the signaling pathways involved, a working hypothesis could be supported by the use of oxysterols (especially oxysterols associated with inflammation and oxidative stress) or phytosterols as biomarkers.
Fig.1 Structure of cholesterol and several common oxysterols. (Jusakul, 2011)
The Role of Anti-oxysterols Antibody in Amyotrophic Lateral Sclerosis (ALS)
ALS is a non-demyelinating neurodegenerative disease in adults with motor disorders. Since lipids are involved in certain signaling pathways, it may be reasonable to look for oxysterols, mainly 25-hydroxycholesterol and its metabolites involved in immune response, or phytosterols as suitable biomarkers for this pathology. Oxysterols have part of the ability to bind to liver-X receptors and other proteins, such as oxysterol binding proteins (OSBP), supporting a potential involvement in ALS. High plasma levels of cholesterol have been suggested to be neuroprotective for the degenerative disease ALS and to be associated with increased survival time. Various data strongly suggest a possible involvement of anti-oxysterols antibodies in ALS and their potential use as biomarkers.
Fig.2 Oxysterols in various neurodegenerative diseases. (Vejux, 2018)
What We Can Do about NAA?
Aided by our well-established platforms and experienced scientists, we can provide comprehensive NAA services to support every step of your program, such as NAA detection, NAA profiling, NAA epitope mapping, etc. Customized NAA service is also within our service range. In addition, a wide spectrum of NAA products is also available for your choice. Our services have many technical advantages, such as high specificity and accuracy, good repeatability without a need for large-scale repeated tests, excellent data analysis services, etc. So, choosing us is your best choice.
Creative Biolabs is well-positioned to deliver focused services to the research market representing the highest value targets for the diagnosis and prognosis of ALS. Equipped with extensive experience and talented experts, Creative Biolabs promises to meet the customized requirements of your research and project about oxysterols biomarker. If you are interested in our services, please do not hesitate to contact us for more details.
References:
- Jusakul, A.; et al. Mechanisms of oxysterol-induced carcinogenesis. Lipids in health and disease. 2011, 10(1): 44.
- Vejux, A.; et al. Biomarkers of amyotrophic lateral sclerosis: current status and interest of oxysterols and phytosterols. Frontiers in molecular neuroscience. 2018, 11: 12.
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