NAA Services for Anti-Platelet Antibody
Possessing world-leading technology platforms and professional scientific staff, Creative Biolabs is always dedicated to assisting our clients with the most satisfactory scientific research services. In terms of anti-platelet antibody and related NAA (natural autoantibodies) research, Creative Biolabs can provide a full range of products and services for our worldwide customers based on our years of experience and high-end technologies.
Background of Anti-Platelet Antibody
Platelet, also known as thrombocyte, is a cell component of blood, which is produced from megakaryocytes in the bone marrow. Actually, platelets are not true cells but fragments of megakaryocytes cytoplasm because they have no cell nucleus. Platelets are the smallest ‘cells’ circulating within blood found only in mammals whose function is to prevent bleeding or blood vessel injury by clumping, thereby causing a blood clot. Too many or too few platelets or having platelets that don’t work as they should in blood all lead to platelet disorders or diseases.
Anti-platelets are a group of autoantibodies against platelet-specific antigens which are an important part of the platelet membrane glycoprotein complexes. Actually, anti-platelets are immunoglobulins of autoimmune origin that can be dated back to as early as the 1950s. They are usually produced by autoimmune response or reaction to transfusion products or medications, which all play a critical role in the immune-mediated platelet disorders.
Fig.1 Platelet responses induced by heparin-induced thrombocytopenia antibodies and functional assay targets.1
The Role of Anti-Platelet in Immune Thrombocytopenic Purpura (ITP)
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder of low platelet count with a bleeding tendency affecting the skin and mucosa. ITP usually results from autoantibody broad reactivity against platelet antigen causing premature immune destruction or increased clearance of platelets by the reticuloendothelial system, especially by splenic macrophages. Diagnosis of ITP mainly relies on complete blood count, together with other laboratory tests and exclusions. Notably, autoantibodies can be biomarkers that play key roles in the clinical diagnosis of ITP.
Anti-platelet autoantibodies are the major NAAs involved in the ITP primary pathogenesis. Anti-platelet antibodies mostly target the glycoprotein complexes in the platelet membrane, such as glycoprotein IIb/IIIa, which are physiological receptors that mediate interactions between platelets and vascular subendothelium in injured blood vessels. IgG and IgM are predominant antibody types isolated from ITP patients, of which IgG anti-platelet antibodies against GPIIb/IIIa are useful markers in ITP.
Fig.2 The influence of anti-platelet antibodies on pathogenic loop in ITP.2
With the abundant research on NAA progresses, Creative Biolabs is capable to provide the largest and diversiform portfolio of NAA products and NAA services. Our proven and optimized platforms can help you quickly get satisfactory results without repeated trials. We also provide custom services based on the requirements of our clients to meet the specific demand. Please feel free to contact us for more details. Our scientists are pleased to tailor the best-fit proposal to match your project.
References
- Tardy, Brigitte, et al. "Detection of platelet-activating antibodies associated with heparin-induced thrombocytopenia." Journal of clinical medicine 9.4 (2020): 1226.
- Consolini, Rita, Annalisa Legitimo, and Maria Costanza Caparello. "The centenary of immune thrombocytopenia–part 1: revising nomenclature and pathogenesis." Frontiers in pediatrics 4 (2016): 102.