NAA Services for Anti-TPO Antibodies
As an acknowledged antibody service provider, Creative Biolabs can offer various NAA services to help our customers obtain ideal laboratory test results, thus contributing to your research and projects successfully. Currently, we provide a full range of anti-TPO marker services for disease diagnosis and treatment. We are confident in providing high sensitivity and high-quality products to our global clients.
Background of Anti-TPO Antibodies
Thyroid peroxidase (TPO) is a membrane-bound, glycosylated, heme-containing protein which contributes to thyroid hormone synthesis. It can catalyze the oxidation of iodide on tyrosine residues in thyroglobulin for the synthesis of triiodothyronine and thyroxine (tetraiodothyronine). TPO is one of the most important thyroid gland antigens and is located on the apical membranes of the thyroid follicular cells. Anti-TPO antibodies are a type of anti-thyroid autoantibodies targeted against TPO in the blood, which are the most clinically relevant anti-thyroid autoantibodies. Autoantibodies to TPO are most commonly associated with Hashimoto's thyroiditis. In addition, anti-TPO antibodies can activate complement system and are considered to be significantly involved in thyroid dysfunction and the pathogenesis of hypothyroidism.
Fig.1 The relationship between thyroid hormonal profile and thyroid autoimmunity: TPO-Ab.1
The Role of Anti-TPO Antibodies in NAA Associated Thyroiditis
Thyroiditis is the inflammation of the thyroid gland that is located on the front of the neck below the laryngeal prominence and produces hormones to mediate a variety of metabolism pathways. Anti-TPO antibodies are specific to TPO autoantigens. Compared with linear epitopes, most of the antibodies produced target the conformational epitopes of the immunogenic carboxyl terminal region of TPO protein. Actually, most of anti-TPO antibodies are produced by thyroid infiltrating lymphocytes, with minor contributions from lymph nodes and the bone marrow. The thyroid cell damage attributes to complement activation and antibody-dependent cell cytotoxicity. Levels of anti-TPO antibodies are increased in greater than 90% of patients with active autoimmune thyroiditis. Statistical data show that anti-TPO antibodies are the most common anti-thyroid autoantibody, located in approximately 95% of patients with chronic lymphocytic thyroiditis, 75% of Graves' disease and 10-20% of nodular goitre or thyroid carcinoma. Therefore, the presence of anti-TPO antibodies is an indication for treatment in those patients with early/ compensated hypothyroidism.
What We Can Do about NAA?
Our NAA services can be implemented through advanced platforms and experienced scientists, including NAA detection, NAA profiling, NAA affinity measurement, NAA epitope mapping, and paratope mapping. A variety of NAA products are available for your choice.
Creative Biolabs is one of the forward-looking service providers for antibody detection and design who leads the development of the era while offering the best service to the customers all around the world. Our seasoned experts in NAA research are pleased to provide NAA services for anti-TPO antibodies marker. We have extensive experience in all kinds of NAA related services. Please do not hesitate to contact us for more details.
Reference
- Popa, Adelina, et al. "Study of the thyroid profile of patients with alopecia." Journal of Clinical Medicine 12.3 (2023): 1115.
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