SLC2A5 Membrane Protein Introduction

Introduction of SLC2A5

Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), also known as fructose transporter or glucose transporter type 5, small intestine (GLUT-5), is a protein in humans that is encoded by the SLC2A5 gene. It is a fructose transporter mainly expressed on the apical border of enterocytes in the small intestine.

Basic Information of SLC2A5
Protein Name	Solute carrier family 2, facilitated glucose transporter member 5
Gene Name	SLC2A5
Aliases	Fructose transporter, Glucose transporter type 5, small intestine, GLUT-5
Organism	Homo sapiens (Human)
UniProt ID	P22732
Transmembrane Times	12
Length (aa)	496
Sequence	MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT

Function of SLC2A5 Membrane Protein

GLUT5 (SLC2A5) is a fructose transporter encoded by the SLC2A5 gene of the SLC2 family. It is primarily expressed in the jejunal region of the small intestine. Lower levels of the protein are found in kidney, brain, skeletal muscle, and adipose tissue. Studies have shown that it could mediate fructose absorption in the jejunum at the apical, potentially also basolateral membrane, of the epithelial cells into the portal vein. During the past years, the expression level of SLC2A5 is associated with numerous diseases. For example, the expression of SLC2A5 is elevated in breast cancer cell lines MCF7 and MDA-MB-231 and associated with higher fructose uptake rate. Recently, it has shown that the expression of SLC2A5 in tumor cells of patients with AML is increased and is negatively correlated with the prognosis of patients. Furthermore, SLC2A5 is significantly upregulated in lung adenocarcinoma patients and overexpression of SLC2A5 is highly correlated with poor patient survival.

Fig.1 Fructose promotes lung adenocarcinoma cell survival and metastasis through SLC2A5. (Weng, 2018)

Application SLC2A5 of Membrane Protein in Literature

Weng Y., et al. SLC2A5 promotes lung adenocarcinoma cell growth and metastasis by enhancing fructose utilization. Cell death discovery. 2018, 4(1):38. PubMed ID: 29531835

This article suggests that SLC2A5 is significantly upregulated in lung adenocarcinoma (LUAD) patients and overexpression of SLC2A5 is highly correlated with poor prognosis of LUAD patients. It indicates that GLUT5 may be used as a potential target alone or in combination with other treatment for lung cancer therapy.
Zhou X., et al. d-Fructose Modification Enhanced Internalization of Mixed Micelles in Breast Cancer Cells via GLUT5 Transporters. Macromolecular bioscience. 2017, 17(7):1600529. PubMed ID: 28346751

This article suggests that PPF MM represents a promising nanoscale carrier system to achieve GLUT5-mediated cell-specific delivery in cancer therapy.
Yan T.Y., et al. The Roles of Glut5 in Imatinib Resistance in the Ph+ Acute Lymphoblastic Leukemia Cell. Sichuan da xue xue bao. Yi xue ban= Journal of Sichuan University. Medical science edition. 2017, 48(3):389-93. PubMed ID: 28616912

This article aims to explore the possible roles of glucose transport 5 (Glut5) in imatinib resistance in the Ph+ acute lymphoblastic leukemia cell (Ph+ ALL). It finds that high expression of SLC2A5 and Glut5 protein in SUP-B15/R cells could lead to increased fructose absorption, and further activates the PI3K/AKT pathway which causes the SUP-B15 cell resistance to imatinib.
Kojo A., et al. Glucose transporter 5 (GLUT5)-like immunoreactivity is localized in subsets of neurons and glia in the rat brain. Journal of chemical neuroanatomy. 2016, 74:55-70. PubMed ID: 27036089

This article aims to determine the distribution of glucose transporter 5 (GLUT5), which preferentially transports fructose, in the rat brain by immunohistochemistry and western blotting. It suggests that GLUT5 may transport fructose in subsets of the glia and neurons for an energy source of these cells.
Du L. and Heaney A.P. Regulation of adipose differentiation by fructose and GluT5. Molecular Endocrinology. 2012, 26(10):1773-82. PubMed ID: 22827929

This article suggests that fructose and GluT5 play an important role in regulating adipose differentiation.

SLC2A5 Preparation Options

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Reference

Weng, et al. (2018). Fructose fuels lung adenocarcinoma through GLUT5. Cell death & disease. 9(5): 557.

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