SLCO6A1 Membrane Protein Introduction

Introduction of SLCO6A1

Solute carrier organic anion transporter family member 6A1 (SLC6OA1) is a transmembrane protein consisting of 719 amino acids encoded by the SLC6OA1 gene. In humans, the SLC6OA1 gene encodes the OATP6A1 (SLC6OA1) protein which is a member of the organic anion transporter protein (OATPs) family. Eleven human OATPs have been identified and are classified into six families (OATP 1-6) based on their amino acid properties. OATP proteins are reported to mediate the sodium-independent membrane transport of numerous endogenous and xenobiotic amphipathic compounds such as bile acids, thyroid hormones, prostaglandins, conjugated steroids, antibiotics, and nonsteroidal anti-inflammatory drugs.

The Function of SLCO6A1 Membrane Protein

SLCO6A1 has 12 transmembrane domains and is responsible for transporting dehydroepiandrosterone sulfate and thyroid hormone, which are supposed to be involved in the regulation of spermatogenesis in the gonads. The gonadal-specific anion transporter encoded by the SLC6OA1 gene exhibits tissue-specific expression. Among normal tissues, SLCO6A1 is expressed strongly only in normal testis. It is expressed weakly in spleen, brain, fetal brain, and placenta, and is absent from all other tissues. In addition, mRNA encoded by SLC6OA1 gene has been detected in lung tumor samples and lung cancer cell lines as well as in bladder and esophageal tumor samples. Frequent expression of SLCO6A1 in tumors suggests that it may play a role in tumorigenesis, possibly by rendering the cells sensitive to hormonal growth stimuli. This also makes it possible to be the target of small molecule therapy.

Fig.1 The predicted transmembrane structure of OATPs. (Liu, 2014)

Application of SLCO6A1 Membrane Protein in Literature

1. Khan R.A.W., et al. Analysis of association between common variants in the SLCO6A1 gene with schizophrenia, bipolar disorder and major depressive disorder in the Han Chinese population. World Journal of Biological Psychiatry. 2016, 17(2): 1. PubMed ID: 26861727
   
   

   This study shows that rs6878284 in the SLCO6A1 gene is not associated with schizophrenia and also predicts that rs7734060 may be a risk locus for major depression in the Han population.

2. Lee S.Y., et al. Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer. Cancer Immun. 2004, 4: 13. PubMed ID: 15546177
   
   

   This article indicates that SLCO6A1 is putative cancer/testis (CT) cell surface antigen with potential utility and can be used as an antibody therapeutic target for a variety of tumor types.

3. Brenner S., et al. Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy. Cancer Letters. 2015, 356(2): 517-524. PubMed ID: 25301452
   
   

   This study shows that OATP may be a novel biomarker for tumor progression and metastasis development in SCLC patients.

4. Buxhofer-Ausch V., et al. Tumor-specific expression of organic anion-transporting polypeptides: transporters as novel targets for cancer therapy. Journal of Drug Delivery. 2013, 2013: 863539. PubMed ID: 23431456
   
   

   This article reports that OATP1B1, OATP1B3, and OATP6A1 are present in various cancer tissues and their limited expression in normal tissues makes them possible targets for tumor immunotherapy.

5. Liu T. and Li Q. Organic anion-transporting polypeptides: a novel approach for cancer therapy. Journal of Drug Targeting. 2014, 22(1): 14-22. PubMed ID: 23987090
   
   

   This review points out that due to the rich expression of OATP in tumors and its high transport activity against many anticancer drugs, it should be considered as an important therapeutic target for anticancer drug design.

SLCO6A1 Preparation Options

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Reference

1. Liu T and Li Q. (2014). Organic anion-transporting polypeptides: a novel approach for cancer therapy. Journal of Drug Targeting. 22(1): 14-22.

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