Apple-derived Exosome Research and Application

Apple is widely recognized for its antioxidant and anti-inflammatory properties, which are believed to help combat cellular oxidative stress and chronic inflammation, thereby reducing the risks of cardiovascular diseases, diabetes, and certain cancers. Therefore, exosomes derived from apples may carry beneficial bioactive molecules such as microRNAs, proteins, and lipids that could play a role in functions like antioxidation and anti-inflammation. Creative Biolabs presents information related to apple-derived exosomes to demonstrate its commitment to seeking innovation and business opportunities in collaboration with clients.

(http://47.109.42.40:8006/images/20180710235450_4830.jpg)

Benefits of Apple

Immune Support: Apples are rich in Vitamin C, Vitamin A, folate, and antioxidants, which contribute to enhancing immune system function and boosting the body's resistance.
Cardiovascular Health: The fiber and antioxidants in apples help lower cholesterol levels, maintain cardiovascular health, and reduce the risks of heart disease and stroke.
Digestive Health: The fiber in apples aids digestion, slows down the movement of food in the digestive tract, helps control weight, and prevents constipation.
Blood Sugar Management: Apples, being rich in fiber, help stabilize blood sugar levels, prevent glucose fluctuations, and are beneficial for diabetes management.
Anti-Inflammatory Effects: Certain compounds in apples are believed to have anti-inflammatory effects, aiding in reducing inflammatory responses and associated diseases.
Anti-Aging: Antioxidants in apples contribute to slowing down the cellular aging process, maintaining healthy skin and overall bodily health.

Research on Apple-Derived Exosome

Building upon the inherent benefits of apples, many researchers have started or are conducting research on exosomes derived from apples. This is because exosomes, as carriers of bioactive molecules, might further enhance these benefits, providing new opportunities for various applications.

Possible Function	Target	Possible Mechanism
Anti-inflammatory	Macrophages	Apple-derived exosomes exert anti-inflammatory effects by modulating miRNA146 in macrophages.
Anti-inflammatory and skin regeneration promotion	Dermal fibroblasts	Apple-derived exosomes promote collagen synthesis and decrease metalloproteinase production in dermal fibroblasts by downregulating the NF-κB pathway.
Impact on intestinal absorption	Human colon adenocarcinoma cells	Apple-derived exosomes affect intestinal absorption by downregulating the expression of organic-anion-transporting polypeptide 2B1 in human colon adenocarcinoma cells.
Impact on intestinal absorption	Human colon adenocarcinoma cells	Apple-derived exosomes downregulate the expression of organic-anion-transporting polypeptide 2B1 by carrying miRNAs (including miR7121d-h, miR160a-e, and miR-7121a-c) in human colon adenocarcinoma cells.
Promotion of intestinal digestion	Intestines	Apple-derived exosomes affect intestinal bile acid transport by downregulating the RARα/ASBT/SLC10A2 pathway.

Outlook for Apple-Derived Exosome

Based on the aforementioned research, apple-derived exosomes could have various potential applications in the future, encompassing health, drug development, skincare, and intestinal function improvement. Some potential applications include:

Anti-inflammatory therapies: This could involve treating chronic inflammatory conditions like arthritis, inflammatory bowel disease, and enhancing immune system function.
Skincare and anti-aging: Future development of skincare products based on apple-derived exosomes could improve skin elasticity, reduce wrinkles, etc.
Intestinal function improvement: Apple-derived exosomes could regulate bile acid transport, offering directions for developing health products to address bile stasis and chronic constipation.
Nutritional and dietary supplements: Apple-derived exosomes carrying beneficial bioactive molecules could be used to develop nutritional supplements and health products for enhancing human well-being.

However, further research is needed to validate the feasibility and effectiveness of these applications. Creative Biolabs has a platform for extracting and developing plant-derived exosomes, supporting research on apple-derived exosomes. Please contact us to leverage our expertise and technology platform to explore the potential applications of apple-derived exosomes in health, drug development, skincare, and more.

Comprehensive Plant-Derived Exosome Development Services at Creative Biolabs

Plant-Derived Exosome Isolation

Plant-Derived Exosome Identification

High-Throughput Screening Analysis (Proteins, RNA, Lipids and Metabolites)

Target Analysis

In Vitro Functional Discovery of Plant-Derived Exosomes

In Vivo Functional Discovery of Plant-Derived Exosomes

Large-Scale Production of Plant-Derived Exosomes

References

Trentini, M.; Zanotti, F.; et al. An apple a day keeps the doctor away: potential role of miRNA 146 on macrophages treated with exosomes derived from apples. Biomedicines. 2022. 10(2).
Trentini, M.; Zanolla, I.; et al. Apple derived exosomes improve collagen type I production and decrease MMPs during aging of the skin through downregulation of the NF-κB pathway as mode of action. Cells. 2022. 11(24).
Fujita, D.; Arai, T.; et al. Apple-derived nanoparticles modulate expression of organic-anion-transporting polypeptide (OATP) 2B1 in Caco-2 Cells. Molecular Pharmaceutics. 2018. 15(12):5772-5780.
Komori, H.; Fujita, D.; et al. MicroRNAs in apple-derived nanoparticles modulate intestinal expression of organic anion-transporting peptide 2B1/SLCO2B1 in Caco-2 Cells. Drug Metabolism and Disposition. 2021. 49(9):803-809.
Usui, S.; Zhu, Q.; et al. Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα. Drug Metabolism and Pharmacokinetics. 2023. 52:100512.