Tumor and Cancer-Targeted Exosome Modification Services
Overview Services Features FAQs
Improving the targeting and therapeutic application of exosomes to tumors and cancers is the focus of current research on delivery systems. Creative Biolabs with a long-term commitment to optimizing exosome delivery to tumors and cancers has accumulated extensive insights into the tissue distribution, payload, and spatiotemporal fate of exosomes after systemic administration. Our specialist scientist team can offer exosome modification strategies and services relevant to a wide range of tumor and cancer targeting.
Overview of Exosomes for Tumor and Cancer Targeting
Since reporting their discovery during reticulocyte maturation, the function of exosomes in participating in organic physiology and pathology has gained the attention of researchers. The biological processes that are engaged involve proliferation, growth, infection and immunity, and the actions within these processes are largely dependent on the production source and environment. Until now, the interest in exosomes has extended to evaluating their value in target distribution and therapeutic development in tumors and cancers. It is unfortunate that natural exosomes still have a suboptimal short circulating half-life and low targeting efficiency in the delivery to tumors and cancers due to the heterogeneous endothelial gap and inadequate blood perfusion in the focal area. The ability of exosomes to be engineered to target tumors and cancers enhances their effective on-target delivery to focal sites.
Fig.1 The preparation and application of exosomes and exosome-mimics as drug delivery vehicles for cancer therapy.1
Exosome Modification Services for Tumor and Cancer Targeting at Creative Biolabs
Creative Biolabs has established a comprehensive platform of services to modify engineered exosomes to target tumors and cancers. On the one hand, we conclude the exosome production sources to screen the appropriate production cell lines for matching the desired information of the investigational target. As well, the obtained exosomes are subjected to adequate endogenous component profiling and effectiveness assessment. On the other hand, we are flexible in providing customized research services for exosome modification according to the requirements of multiple types of tumors and cancer-specific targeting in diseases including but not limited to:
Features of Exosome Modification for Tumor and Cancer Targeting at Creative Biolabs
Optimizing membrane properties by altering and modifying exosome components is the primary strategy for tumor- and cancer-targeted exosome production at Creative Biolabs.
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On the one hand, passive enrichment of exosomes based on enhanced EPR effects is a prerequisite for subsequent targeting of specific focal lesion cells. Specifically, prolonging the circulating half-life is realized by increasing the display of components related to anti-phagocytosis and anti-clearance properties on the exosome membrane surface.
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On the other hand, the cell-specific uptake of exosomes is manipulated by increasing the ligands on the exosome membrane surface that bind to specific cell surface highly expressed or particular proteins in diseased cells or TME.
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Besides, it is also feasible to alter the transcriptome of donor cells by modification, given that donor cells can affect the tissue-homing properties of exosomes as well.
Fig.2 Drug loading strategies of exosomes and exosome-mimics.1
FAQs
Q: How do tumor-targeted exosomes work?
A: Tumor-targeted exosomes are engineered to carry specific molecules or ligands on their surface that enable them to recognize and bind to tumor cells selectively. Once bound, these exosomes can deliver therapeutic payloads, such as drugs or nucleic acids, directly to the cancer cells, minimizing off-target effects and enhancing treatment efficacy.
Q: How are tumor-targeted exosomes produced?
A: Tumor-targeted exosomes can be generated through various methods, including:
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Cell engineering: Modifying donor cells to produce exosomes with desired targeting properties.
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Exosome isolation and modification: Isolating exosomes from cell culture supernatants or bodily fluids and then modifying their surface or cargo.
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Synthetic exosome mimetics: Engineering synthetic nanoparticles to mimic the properties of natural exosomes, including tumor targeting.
With a long-term approach to screening exosomes for enhanced focal tissue deposition and payload delivery, Creative Biolabs provides clients with exosome modification-related services targeting a diverse range of tumors and cancers, facilitating progress in research for the rational design of exosome delivery tools. Please contact us for a quote.
Reference
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Yang, Fuxu, Mingyue Wang, and Xingang Guan. "Exosomes and mimics as novel delivery platform for cancer therapy." Frontiers in Pharmacology 13 (2022): 1001417. Under Open Access license CC BY 4.0, without modification.
For Research Use Only. Cannot be used by patients.
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