Lung Cancer-targeting Adenovirus Vector Construction Service
With the continuous development of molecular biotechnology and the emergence of various biological research tools, gene therapy has become a key area of modern medical research because of its safety and stability. As a leader in the adenovirus vector (AV) construction, Creative Biolabs has established an advanced AV construction platform. Through continuously technical accumulation, we have launched advanced lung cancer-targeted adenoviral vector construction service to provide safe and reliable molecular tools for your research.
Lung Cancer-targeting Gene Therapy
Lung cancer is a malignant tumor with extremely high mortality, which seriously endangers human health. The incidence rate has always been at the forefront of various types of cancer. In the past few decades, medical technology for lung cancer has progressed slowly, and the survival rate of patients with non-small cell lung cancer (NSCLC) has hardly improved; the survival of patients with small-cell lung cancer (SCLC) has been extended with the development of chemotherapy technology, but there have been few cases that are completely cured. Therefore, it is an urgent need for the emergence of new and effective treatments.
With the gradual maturity of DNA recombination technology and gene transfer technology, gene therapy for lung cancer has become a promising treatment. It targets the molecular characteristics of lung cancer and uses gene transfer technology to introduce foreign genes into tumor cells or other cells to correct or compensate for defective genes. There are many advantages of gene therapy for lung cancer. The broad epithelial cells on the surface of the lungs facilitate the introduction of foreign genes. During the course of treatment, specific receptor cells can be obtained by lung biopsy to observe the therapeutic effect. Therefore, the development of lung cancer' gene therapy is very rapid. For instance, recombinant adenovirus-mediated p53 gene transfer can significantly enhance the drug sensitivity of lung cancer cells. Obviously, it will become a routine treatment in the future.
Adenovirus Vector for Gene Therapy
The most critical and difficult part of gene therapy is the choice of suitable vectors. A good vector must be able to specifically carry the gene of interest to the target organ and express at a certain level for a certain period of time to exert therapeutic effects. Adenoviruses are most widely used in the treatment of lung diseases due to their tendency to the lungs. Adenovirus can not only insert large fragments of DNA, but also infect dividing and resting cells as well as some other cells that the retrovirus cannot infect. Adenovirus can express a large amount of protein independent of the proliferation of host cells, and avoid the inefficiency of treatment due to slow replication of airway epithelial cells. In addition, adenovirus can proliferate itself in the intestines and respiratory tract, so the gene transfer can be carried out through various methods. Intravenous injection of recombinant virus, and making the recombinant virus into a capsule or a drug are both effective. Oral administration or spraying is easier to popularize. In gene therapy for NSCLC, a recombinant AV supplemented with a cytomegalovirus promoter can specifically express E2F-1 in NSCLC, demonstrating a good therapeutic effect in clinical trials.
Creative Biolabs provides you with high-quality adenoviral vectors as a tool for gene delivery in vivo and in vitro. Our vectors are more specific, safer and more stable. The construction of a vector targeting lung cancer will continue to be the focus of our work for a long time in the future, and we look forward to establishing a long-term cooperative relationship with you. If you have any questions or have any difficulties, you can contact us by email or send us an inquiry to find a complete solution.
