Cell Penetrating Scaffold Discovery Service

Creative Biolabs has been a long-term expert in the field of scaffold discovery. Based on years of experience and advanced Super™ Intrabody Development Platform, we can now provide novel cell penetrating scaffold discovery service for our clients all over the world.

What is Cell Penetrating

Proteins are potential small-molecule reagents against disease-related targets because of the flexible size, complex structure, and important functions. However, the presence of tissue and cell barriers together with the low biomembrane permeability of most therapeutic proteins largely limits the systemic distribution. In this case, various chemical or mechanical methods are used to transfect cells with genes, micro-RNA, plasmids, and oligonucleotides. However, the current approaches may lead to high toxicity, low delivery yield, as well as immunogenicity. Besides, these methods are always not suitable for animal studies and in vivo experiments. Hence, the novel techniques are required to cross the lipid bilayer membrane of mammalian cells.

Introduction of Cell Penetrating Scaffold

Scaffolding proteins are modular proteins that assemble macromolecular signaling complexes or multimolecular signaling complexes and also modulate the function of associated proteins. Engineered protein scaffolds are important tools for a wide range of pharmaceutical and biotechnological applications. Thanks to their favorable biophysical and chemical characterizations, possibilities of engineered protein scaffolds have been explored in biological diagnostics and therapeutics. Now Creative Biolabs focuses on cell penetration properties to further improve the intracellular effect of the scaffold proteins. Based on our advanced mutant library construction technology and Super™ platform, our scientists have developed engineered cell penetrating scaffolds endowed with potential to recognize any desired targets to further expand the range of applications.

Figure 1. Functions of scaffold proteins.

Feature of Cell penetrating Scaffold

• 100% precise mutant with the expected size of over 10¹⁰.
• Ability for cell penetrating.
• Available for almost all the targets
• High stability and great solubility

Creative Biolabs has long-term devoted to the development and application of protein scaffolds development, we can provide versatile strategies to desired scaffolds. Depending on novel research methods and tools, we are capable of meeting the specific need of each customer with the best project design. As a forward-looking as well as a leading custom service provider in the field of scaffold discovery, Creative Biolabs has won a good reputation among our worldwide customers for successfully accomplishing numerous challenging projects. If you are interested in our services, please do not hesitate to contact us for more details.

All of our antibody products and services can only be used for preclinical research studies. Do not use them on humans.