TransMab Discovery Service

Creative Biolabs has been a long-term expert in the field of novel antibodies discovery. Based on our Super™ transbody development platform, we can provide a series of TransMab discovery services to meet the growing demands for diagnostic and therapeutic applications.

Introduction of TransMab

As a popular agent, monoclonal antibodies have confirmed their efficiency against various cell-surface targets. Beyond that, there are still many intracellular protein targets existing. While conventional antibodies are facing difficulties to recognize such intracellular targets in living cells due to their large size and lack of membrane permeability. Interestingly, the natural autoantibodies against DNA or nuclear ribonucleoproteins present the ability to penetrate the cellular and nuclear membranes of living cells. In this case, it might be possible to endow normal antibodies with the membrane-penetrating property through specific design and modifications. Creative Biolabs has built the novel Super™ TransMab platform which enables antibodies to be shuttled into living cells without harming them. Compared with the peptide inhibitors and normal antibodies, TransMabs have a series of advantages and present great potentials in either diagnostic or therapeutic applications.

TransMab Discovery at Creative Biolabs

Studies have shown that specialized protein sequences are necessary to facilitate viruses’ entry. Our Super™ TransMab platform can convert normal antibodies into TransMabs with enhanced membrane transporting capacity. Certainly, these TransMabs present great potentials as diagnostic reagents. Based on our professional antibody development and modification technology, Creative Biolabs can offer comprehensive services from the early stage of antibody discovery to the development of efficient TransMabs.

Advantages of TransMab

• Lower toxicity in patients or target organ toxicity
• Higher pharmacokinetic up to one millionfold
• Rapid feasibility assessment
• Great specificity, with reactivity to single, conformational-dependent epitopes can distinguish isoforms and activated forms

Equipped with world-leading technology platforms and professional scientists, Creative Biolabs is always dedicated to assisting our clients with the most satisfactory Transbody related services. If you are interested in our TransMab discovery service, please do not hesitate to contact us for more details.

All of our antibody products and services can only be used for preclinical research studies. Do not use them on humans.