Clodronate Liposome is a multilamellar liposome suspension in which clodronate is encapsulated in the aqueous compartments of the liposomes. When animals or cells are treated with Clodronate Liposome, phagocytic cells recognize the liposomes as invading foreign particles and proceed to remove the liposomes from the local tissue or serum via phagocytosis. The liposomes then release clodronate into the cytosol, resulting in cell death. Non-encapsulated clodronate cannot cross the cell membrane to initiate cell death.
Upon administration, Clodronate liposomes are recognized by phagocytic cells as foreign entities. These cells ingest the liposomes, which then release clodronate into the cytosol, leading to cell death.
Why use Clodronate liposomes over non-encapsulated clodronate?
Clodronate encapsulated within liposomes can cross cell membranes via phagocytosis, which is not feasible with non-encapsulated clodronate, ensuring targeted cell death.
What is the advantage of using Clodronate liposomes in research?
Clodronate liposomes offer a selective method to deplete phagocytic cells, facilitating studies on immune function and disease without affecting other cell types.
Are there any specific storage conditions for Clodronate liposomes?
Clodronate liposomes should be stored at controlled room temperatures and protected from prolonged exposure to light to maintain stability and efficacy.
Efficient Delivery System
The clodronate liposomes provided by Creative Biolabs displayed remarkable delivery efficiency. Their stability and high efficacy in laboratory tests significantly improved the research outcomes.
Exceptional Cellular Penetration
Excellent product! The penetrative ability of the clodronate liposomes in cell culture experiments was impressive. It enhanced cell absorption rates, greatly increasing the reliability of experimental results.
Consistent Product Quality
Consistent and repeatable results were obtained each time the clodronate liposomes were used. Such consistency is crucial for long-term research projects.
User-Friendly Packaging Design
The packaging of this product is both practical and easy to handle. Easy access and usability significantly increased efficiency in lab work.
Outstanding Technical Support
Excellent technical support and customer service were experienced when using the clodronate liposomes. Any queries and issues were quickly addressed, enhancing confidence in their use.
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