This formulation is Doxorubicin Liposome (PEGylated) with the carboxyl group, which can be activated by EDC (1-ethyl-3-[3-dimethylaminopropyl] carbodiimide) and react with sulfo-NHS (N-hydroxysulfosuccinimide) to produce a significantly more stable and more soluble active intermediate (NHS ester). The intermediate can covalently conjugate to the amine group on the proteins, peptides or antibodies through displacement of sulfo-NHS group by amine.
What is the purpose of PEGylation in these liposomes?
PEGylation enhances the stability and solubility of the liposomes in biological environments.
What types of molecules can be conjugated to the Succinyl-Doxorubicin Liposome (PEGylated)?
Proteins, peptides, and antibodies with free amine groups can be conjugated.
In what buffer is the activation and conjugation reaction most efficient?
The reaction is most efficient in PBS at pH 7.2-7.5.
Can these liposomes be used for targeted drug delivery?
Yes, they are designed for targeted drug delivery applications.
How often should the solutions of EDC and sulfo-NHS be prepared?
They should be prepared fresh before each use to ensure maximum efficiency.
Enhanced Antitumor Activity
Using Creative Biolabs' Succinyl-Doxorubicin Liposome (PEGylated) in our cancer research has tremendously improved the antitumor activity of doxorubicin.
Superior Drug Delivery
The PEGylated liposomes from Creative Biolabs have significantly enhanced the bioavailability of our experimental drugs in vivo.
Maintained Biological Activity
We were impressed that the biological activity of our proteins was preserved during the conjugation process.
Excellent Performance in Cancer Research
These liposomes have shown enhanced antitumor activity in our studies compared to standard doxorubicin therapies.
High Quality Assurance
The liposomal formulations provided have met our high expectations for quality - a testament to Creative Biolabs' reputation in the field.
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For Research Use Only. Not For Clinical Use 
