Magic™ Membrane Protein Human GLP1R (Glucagon like peptide 1 receptor) (CAT#: MP0015F)

Datasheet

The glucagon-like peptide-1 receptor (GLP-1R) is a class B GPCR that is a major therapeutic target for the treatment of type 2 diabetes. The receptor is activated by the incretin peptide GLP-1 (Glucagon Like Peptide) promoting a broad range of physiological effects including glucose-dependent insulin secretion and biosynthesis, improved insulin sensitivity of peripheral tissues, preservation of β-cell mass and weight loss, all of which are beneficial in the treatment of type 2 diabetes.

Product Specifications

Host Species
Human

Target Protein
GLP1R

Protein Length
Full Length

Protein Class
GPCR Class B

Molecular Weight
53 kDa

Sequence
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS

Product Description

Activity
Validated by SPRi

Application
Screening & display technologies, Structural biology, Antibody development

Expression Systems
Cell-free expression system in the presence of lipid vesicles

Tag
Histidine tag fused to the N-terminal end of the protein

Protein Format
Proteoliposome

Purification
Sucrose gradient

Purity
>50% by SDS-Page and Coomassie Blue staining

Buffer
Tris 50mM, pH 7.5

Target

Target Protein
GLP1R

Full Name
Glucagon like peptide 1 receptor

Introduction
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.

Alternative Names
GLP-1, GLP-1R, GLP-1-R

Gene ID
2740

UniProt ID
P43220

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Q&As

What is the activation mode of GLP1R?

The binding mode of GLP-1R and ligand is mainly the well-known "two-domain model". The C-terminus of the ligand first binds to the extracellular domain of the GLP-1R, which changes the spatial conformation of the GLP-1R and exposes the binding site of the core domain, and then the N-terminal end of the ligand binds to the core domain of the GLP-1R, which activates the GLP-1R. In general, the main role of the extracellular domain of the GLP-1R is to recognize specific ligands, while the core domain plays an important role in signal specificity transmission.
2022-12-25

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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