NAA and Atherosclerosis
As a reputable and experienced supplier, we have specialized in NAA detection and analysis for decades. Based on an advanced specialized platform and skilled technical team, Creative Biolabs is committed to providing flexible one-stop NAA services to accelerate your atherosclerosis-related research projects.
Overview of Atherosclerosis
Atherosclerosis is a common chronic inflammatory disease that occurs worldwide. Atherosclerosis presents in large and medium-sized arteries and is mainly characterized by diffuse medial intimal fibrosteatosis. Scientists have found that atherosclerosis is strongly associated with the onset of stroke, heart failure, and peripheral vascular disease. Atherosclerosis involves multiple factors, such as age, smoking, metabolism, infectious agents, and genetic factors. Although various factors have different effects on lesion formation, the growth of atherosclerotic lesions is closely related to low-density lipoprotein (LDL) levels and dysfunctional high-density lipoprotein (HDL) levels. Notably, oxidation of LDL plays a central role in the atherosclerotic process and produces a variety of oxidatively modified lipids and proteins that represent determinants of the high immunogenicity of the immune system.
Pathology of Atherosclerosis
Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima, and the balance of anti-inflammatory and pro-inflammatory mechanisms is decisive for the final clinical outcome. The hallmark of chronic atherosclerotic inflammation is the progressive accumulation of lipids and inflammatory cells. Indeed, extracellular modification of infiltrating plasma lipoproteins may be an early event in atherosclerosis. Intimal infiltration and modification of plasma-derived lipoproteins are taken up by macrophages, followed by the formation of lipid-laden foam cells that initiate the formation of atherosclerotic lesions. While foam cells are beneficial in atherosclerotic lesions early in their formation, they can be detrimental in advanced lesions, as foam cells die and release their contents into the extracellular space, thereby worsening the inflammatory state of the plaque and structural stability.
Fig.1 Atherogenesis stages (A) and the dynamic process of atherosclerosis (B).1
Services in Creative Biolabs
- Anti-Oxidized Low-Density Lipoprotein (oxLDL)
- Anti-Phosphorylcholine (PC)
- Anti-Phospholipid
- Anti-Cardiolipin
- NAA Services for Anti-β2-glycoprotein-I Antibody
- Anti-HSP 60/65
Related Products in Creative Biolabs
| Target | Product name | Cat.No |
|---|---|---|
| LDL autoantibodies | Human Oxidized LDL Autoantibody (IgG) ELISA kit | NAK-004 |
| Cardiolipin autoantibodies | Human Cardiolipin, Phosphatidyl Serine, Phosphatidyl Inositol, and Phosphatidic acid Autoantibody (IgG&IgM) ELISA kit | NAK-053 |
| dsDNA autoantibodies | Human dsDNA Autoantibody (IgG) ELISA kit | NAK-035 |
| dsDNA autoantibodies | Human dsDNA Autoantibody (IgG&IgM&IgA) ELISA kit | NAK-036 |
NAA has extremely broad application prospects in the research of inflammation-related diseases. Creative Biolabs focuses on providing accurate NAA analysis and detection services to help our customers accelerate the research process. We will develop a reasonable solution based on each client's unique needs. Please contact us in time for more details.
Reference
- Li, Mengqi, et al. "The emerging role of rho guanine nucleotide exchange factors in cardiovascular disorders: insights into atherosclerosis: a mini review." Frontiers in Cardiovascular Medicine 8 (2022): 782098.