NAA Services for Fluorescent Anti-Nuclear Antibodies (FANA)
As an industry leader in the field of natural autoantibody (NAA) research and development, Creative Biolabs is committed to providing the most comprehensive autoantibody-related services for our global clients. We now provide services to fluorescent anti-nuclear antibodies (FANA) with the best quality and the most competitive prices. Moreover, we also offer custom-built services to suit the exact requirements of our clients.
Background of Fluorescent Anti-Nuclear Antibodies (FANA)
Fluorescent antinuclear antibody (FANA) test is commonly used in autoantibody detection for different autoimmune diseases and infectious diseases. Immunofluorescent microscopy is the gold standard method. In this method, the lab takes a slide coated with fixed, permeable cells and adds some of the patient's serum to that slide. The serum is allowed to incubate and is then washed off. FANA test is cool because the experimenter can tell not only if antibodies are present (by seeing green stuff on the cell nuclei) but also what kind of antibodies they might be (by seeing what pattern is present). Different patterns include homogeneous (diffuse) pattern, speckled pattern (random speckles all over the nucleus), nucleolar pattern (a few spots of green within the nucleus), rim or peripheral pattern (green around the periphery of the nucleus). The predictive value of a positive or negative FANA test result was calculated using different pretest probabilities based on clinical criteria.
Fig.1 Classical patterns of anti-nuclear antibodies (left to right. nuclear homogenous, coarse speckled and peripheral pattern).1
The Role of Fluorescent Anti-Nuclear Antibodies (FANA) in Malaria
Malaria, a mosquito-borne infectious disease, affects humans and other animals caused by parasitic single-celled microorganisms belonging to the Plasmodium group. Antigen non-specific immunological derangements in malarial infections are well known for immunosuppression and autoantibody formation. In one case, it has been reported that on the first day of admission, 31.1% of the patients had positive FANA. The incidences of positive FANA rose progressively with times when the patients returned for the 2- and 4-weeks follow-ups after discharge, although most of their malaria was cured. Besides, FANA is significantly correlated with the initial hyper-IgM. Almost all of the positive FANA were the speckled type of nuclear staining. The antigen specificity of the speckled FANA was found not to be the double-stranded DNA or the extractable nuclear antigens.
What Can We Do About NAA?
Experienced in antibody analysis and with dedicated commitment to the scientific community, Creative Biolabs has perfected our technical pipelines in the development of diverse NAA-based services and products. We can provide comprehensive NAA services, such as NAA detection and NAA profiling with high accuracy and high sensitivity. A wide spectrum of NAA products is available for your choice. We would like to share our knowledge and passion in this field to promote the advances of science and for a better tomorrow. If you are interested in our services, please contact us for more information and a detailed quote.
Reference
- Pradhan, Vandana, et al. "Fc γ RIIA Genotypes and Its Association with Anti-C1q Autoantibodies in Lupus Nephritis (LN) Patients from Western India." Autoimmune Diseases 2010 (2010).