NAA Services for Anti-KM-HN-1

KM-HN-1 is a novel cancer/testis antigen which can elicit humoral immune responses in patients with various types of cancer. Creative Biolabs has successfully developed a series of innovative and diversified NAA (natural autoantibodies) platforms to provide fast and convenient services for our worldwide customers. At present, we are able to provide a full range of anti-KM-HN-1 marker services for diseases diagnosis and therapeutic monitoring. Our professional team is optimized to help you get a milestone development in your NAA project.

Background of Anti-KM-HN-1

KM-HN-1 is a human gene which encoded a protein with an amino acid length of 833 and a mass of 96.7 kDa. The cancer/testis antigen KM-HN-1 is a new member of centrosome localizing proteins and the C-terminal coiled-coil region and the leucine zipper motif are important for proper centrosomal localization. These coiled-coil region containing proteins play diverse biological functions as components of the cytoskeleton, nuclear matrix, centrosomes, spindle pole bodies, centromeres, and Golgi apparatus. KM-HN-1 was identified in the serum of a patient with squamous cell carcinoma of the head and neck by means of serologic identification of antigens. The aberrant expression of the KM-HN-1 gene in a broad spectrum of human neoplasms characterizes KM-HN-1 as a cancer antigen. It was recognized by cellular and humoral immune responses from a number of patients suffering from a variety of cancer types.

The Role of Anti-KM-HN-1 in Gastric Cancer

Gastric cancer (GC) is a major public health problem and is the second leading cause of cancer-related death in the world, and effective diagnosis is extremely important for a good outcome. Generally speaking, immunotherapy and especially immune checkpoint-directed therapy are now revolutionizing the management of the oncological disease. Cancers are antigenic and provoke immunity, but manage to escape the host immunity via a variety of mechanisms including activation of so-called checkpoints: inhibitory elements to limit self-damaging autoimmunity. Measurement of autoantibody response to multiple tumor-associated antigens (TAAs) in an optimized panel assay to discriminate patients with early-stage gastric cancer from normal controls may aid in the early detection of gastric cancer. KM-HN-1 is a novel human cancer/testis (CT) antigen which has become a promising target for the diagnosis and immunotherapy for patients with various tumors because of their unique expression patterns. The research shows that KMHN-1-specific cytotoxic T-lymphocytes (CTLs) could be generated from both healthy donors and patients with gastric cancer, which indicated that KM-HN-1 can be a candidate for an ideal target for gastric cancer immunotherapy.

Gastric cancer Fig.1 Metastatic routes and sites in gastric cancer. (Li, et al., 2018)

What We Can Do About NAA?

NAAs are normal components of the humoral arm of the immune system found in clinically healthy individuals. We can provide comprehensive NAA services from NAA detection, NAA profiling, to NAA epitope mapping by our well-established platforms and experienced scientists. A wide spectrum of NAA products is available for your choice.

Creative Biolabs with the proven and optimized platforms can help you quickly get satisfactory results without repeated trials. We also provide custom services based on the requirements of the clients to meet the specific demand. Please allow us to demonstrate our commitment to providing you high-quality products along with personal, prompt, and courteous service. If you have questions, comments, or recommendations for new products or services, please contact us.

Reference:

  1. Li, W.; et al. Molecular alterations of cancer cell and tumour microenvironment in metastatic gastric cancer. Oncogene. 2018, 37(36): 4903-4920.
For Research Use Only | Not For Clinical Use

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