Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsIn the ever-evolving field of antibody research, understanding the impact of pH on antibody binding and stability is crucial for developing therapeutic antibodies that can withstand a wide range of physiological environments. By expressing antibodies on the surface of yeast cells and utilizing high-throughput screening, we can rapidly evaluate interactions between the antibodies and target antigens under various pH conditions. This process enables us to identify antibodies that exhibit desirable binding affinities and specificities, particularly those that exhibit changes in binding behavior under different pH conditions - an essential trait for therapeutic antibodies used in environments such as the acidic tumor microenvironment or the varied pH conditions encountered during drug delivery.
| Species | Antibody Library ID | Display Technology | Library Format | Library Size |
| VHH (Llama) | LlaVHH-YDP-1 | Yeast Display | Naïve VHH | 1.5×108 |
| Human | HuscL-YDP-3 | Yeast Display | Naïve scFv | 1.9×108 |
We offer an extensive array of yeast display library screening services designed to meet the diverse needs of both research and therapeutic applications. Our expertise spans various antibody formats, providing specialized solutions for a wide range of tasks. For more details, please explore the services below:
Premade Yeast Display SdAb Library Screening
Premade Yeast Display ScFv Library Screening
Yeast Display Immune Antibody Library Screening
Yeast Display Antibody Library Screening for Cell-based Target
Yeast Display Library Screening for Mutant Epitope Specific Antibody
Yeast Display Library Screening for TCR-Like Antibody
Yeast Display Library Screening for Anti-GPCR Antibody
We begin by constructing a diverse yeast display antibody library that encodes a wide range of antibody candidates (scFv, Fab, or VHH), designed to maximize the likelihood of finding pH-sensitive binders.
We then expose the library to your target antigen under controlled pH conditions and measure binding affinities and select antibody candidates that show pH-dependent binding.
After screening, we identify the most promising antibody candidates that demonstrate strong and selective binding at specific pH levels. These candidates are further validated and characterized for downstream applications.
Our team provides detailed binding kinetics and structural information for the selected antibodies, ensuring they meet the functional requirements for your therapeutic or diagnostic needs.
Leverage our extensive yeast display libraries to identify novel antibody candidates with high specificity and affinity under a range of pH conditions.
Screen antibodies for changes in binding affinity at different pH levels, simulating conditions found in the bloodstream, tumors, or other biological environments.
We use precise pH control during screening to simulate physiological environments, ensuring that the antibodies identified are optimal for real-world applications.
Advanced flow cytometry tools enable detailed analysis of antibody binding, allowing for the identification of antibodies with specific binding characteristics at different pH levels.
Our platform enables fast, high-throughput screening, providing you with rapid identification of promising antibody candidates without compromising quality.
Tumor Targeting
Antibodies that exhibit enhanced binding in acidic environments can be utilized in cancer therapies to selectively target tumor tissues, which are often more acidic than healthy tissues.
Drug Delivery Systems
pH-sensitive antibodies can improve the targeting and release of therapeutics, such as in antibody-drug conjugates (ADCs) that are activated in acidic environments like those found in tumors or intracellular compartments.
Immuno-Oncology
Discover antibodies that can be engineered to selectively bind to antigens in low-pH environments, enabling more effective immune responses against tumors.
Vaccine Development
pH-dependent antibodies can be used in vaccine development to improve delivery systems that rely on targeting specific cells or tissues in different pH conditions.
Creative Biolabs builds a powerful platform for identifying and optimizing antibodies that demonstrate pH-sensitive binding characteristics, which is vital for applications in targeted therapies, immuno-oncology, and drug delivery systems. Our service is designed to help you find the right candidates faster, more efficiently, and with precision and our expertise and cutting-edge technology can help accelerate your research and development. Please contact us today to learn more about how our pH-dependent antibody screening services can support your research and development goals. We are here to help you achieve success in your antibody discovery journey.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
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