SLCO1C1 Membrane Protein Introduction

Introduction of SLCO1C1

SLCO1C1, the official full name is solute carrier organic anion transporter family member 1C1. SLCO1C1 is also known as solute carrier family 21 member 14 (SLC21A14). It is encoded by the SLCO1C1 gene in humans and belongs to SLC21A family of solute carriers. This gene is conserved in chimpanzee, cow, rat, dog, frog, and zebrafish. It has been documented that 153 organisms have orthologs with this gene. SLCO1C1 is shown to be widely expressed in brain, fat and 3 other tissues, and is involved in the uptake of organic anions.

Basic Information of SLCO1C1
Protein Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Aliases	OATP14, OATP1C1, OATPF, SLC21A14
Organism	Homo sapiens (Human)
UniProt ID	Q9NYB5
Transmembrane Times	12
Length (aa)	712
Sequence	MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISNECEVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL

Function of SLCO1C1 Membrane Protein

SLCO1C1 is a member of the sodium-independent organic anion transporter family and mediates cellular uptake of organic anions. This transmembrane transporter is involved in sodium-independent uptake of thyroid hormones in brain tissues. The affinity of SLCO1C1 for thyroid hormones thyroxine, tri-iodothyronine is particularly high. In addition, the gene polymorphisms are associated with fatigue and depression in patients with hyperthyroidism. Multiple transcript variants can be generated due to alternative splicing. Moreover, SLCO1C1 is regulated in a parallel manner with MCT8 during inflammation at the blood-brain barrier (BBB) and they are essential for thyroid hormone access to the brain. SLCO1C1 is able to control skeletal muscle regeneration in satellite cell activation, and it shows that finely tuned thyroid hormone signaling is very important during myogenesis. Furthermore, PDE3A-SLCO1C1 genetic variant has no relationship with an anti-TNF response in UK patients with rheumatoid arthritis cohort.

Fig.1 Rat SLCO1C1 membrane topology. (Westholm, 2010)

Application of SLCO1C1 Membrane Protein in Literature

Mayerl S., et al. Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration. Stem Cell Reports. 2018, 10(6): 1959-1974. PubMed ID: 29706500

This article indicates that the SLCO1C1 is able to control skeletal muscle regeneration in satellite cell activation, also it shows that finely tuned thyroid hormone signaling is very important during myogenesis.
Lu C.C., et al. cDNA Microarray Analysis and Influx Transporter OATP1B1 in Liver Cells After Exposure to Gadoxetate Disodium, a Gadolinium-based Contrast Agent in MRI Liver Imaging. In Vivo. 2018, 32(3): 677-684. PubMed ID: 29695578

This article shows an increased SLCO1C1 mRNA expression with 2.62-fold in gadoxetate disodium-treated cells.
Hagos L. and Hülsmann S. Unspecific labeling of oligodendrocytes by sulforhodamine 101 depends on astrocytic uptake via the thyroid hormone transporter OATP1C1 (SLCO1C1). Neurosci Lett. 2016, 631: 13-8. PubMed ID: 27519929

This article indicates that L-thyroxin can block SR101 transport into astrocytes through competitive inhibition of the SLCO1C1 transporter, and this can significantly reduce oligodendrocyte labeling.
Smith S.L., et al. Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort. Pharmacogenomics. 2016, 17(7): 715-20. PubMed ID: 27180831

This article shows that PDE3A-SLCO1C1 genetic variant has no relationship with an anti-TNF response in UK patients with rheumatoid arthritis cohort.
Wittmann G., et al. Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents. Endocrinology. 2015, 156(4): 1552-64. PubMed ID: 25594699

This article demonstrates that SLCO1C1 is regulated in a parallel manner with MCT8 during inflammation at BBB and it is essential for thyroid hormone access to the brain.

SLCO1C1 Preparation Options

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Reference

Westholm D E, et al. (2010). Evidence of evolutionary conservation of function between the thyroxine transporter Oatp1c1 and major facilitator superfamily members. Endocrinology. 151(12): 5941-51.

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