Porcine Astrovirus Vaccine
Astrovirus is capable of infecting a wide variety of species and is an important cause of acute diarrhea. Creative Biolabs has been focusing on the vaccine industry and has established a professional research team over a decade to develop comprehensive vaccine products and services. We have done a lot of research on the porcine astrovirus vaccine and have solid experience, so we are of full confidence to provide reliable products and services for your PAstV vaccine research.
Porcine Astrovirus
Astrovirus (AstV) is capable of infecting a large range of hosts, but the same virus generally only infects specific species. As one of them, Porcine astrovirus (PAstV) mainly infects pigs. Currently, PAstV has been found to contain at least five lineages, and all of these viruses are transmitted in pigs in the United States. Porcine astrovirus is found worldwide, but the prevalence of kinds of viruses varies among herds. Virus isolates from the same herd also have high variability and genetic diversity, and viruses of different serotypes exhibit different virulence. After PAstV infection, the pigs usually show mild, self-limiting diarrhea symptoms. The affected animals are usually piglets. Recently, several reports from pig farms in the US and Hungary indicated that PAstV may be related to neurological diseases and the virus causing this disease was classified as PAstV-3. There have been cases where the same animal was co-infected with multiple PAstVs. Although AstVs has previously been considered to be species-specific for host infection, phylogenetic analysis showed that the virus may have the possibility of interspecific recombination. It is unclear whether PAstV is the leading cause of porcine diarrhea because the presence of the virus is found in asymptomatic and symptomatic pigs.
Immunity against PAstV
At present, the understanding of the pathogenesis of diarrhea caused by PAstV is not deep enough. It has been thought that the virus is colonized in the intestine. Seven days after PAstV infection, the virus will be shed in the animal's feces. After 14 days of infection, the virus neutralizing antibodies will begin to develop. Chickens immunized with the baculovirus-expressed CAstV capsid protein fused to the GST tag produced antibodies against CAstV 4 weeks after inoculation, but it is not known whether these antibodies can provide sufficient protection for chickens. Cross-protection between AstV has not been observed so far, and antibodies are generally also specific for their capsid proteins. The relationship between antigens of different strains of AstV is currently not known, and antibodies against PAstV cannot react with bovine AstV.
Development of Vaccines against PAstV
There are currently no commercial PAstV vaccines available on the market. The baculovirus-expressed CAstV capsid protein is capable of inducing virus-specific antibodies in chickens that are immunized, so similar ideas and techniques are of potential in considering from the perspective of designing a PAstV vaccine.
Services in Development of PAstV Vaccine
- Epitope prediction, screening, and identification
- Design of various types of vaccines
- Rich and high-quality protein expression system
- Optimization of vaccine formulation
- Vaccine potency test
- Vaccine production for customized scale
Creative Biolabs always puts the needs of its customers first, always keeps up with the latest vaccine research progress, polishes product quality, improves serving level, and always treats every customer's needs with a sincere attitude. If you are interested in our products and services, please do not hesitate to contact us!
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
