Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe free fatty acid receptor (FFAR) is a G-protein coupled receptor which is activated by free fatty acids (FFAs) and binds free fatty acids. FFARs have been identified by a strategy of the GPCR deorphanization derived from the Human Genome Database. FFARs are essential in physiological processes and various pathophysiological processes. It plays an important role not only as essential nutritional components but also as signaling molecules in numerous physiological processes. FFARs act as a physiological sensor of food-derived free fatty acids and digestion products in the gastrointestinal tract. In addition, they are thought to be involved in modulating energy metabolism mediated by the secretion of insulin and incretin hormones. It also regulates the sympathetic nervous system, taste preferences and inflammatory responses associated with insulin resistance. FFARs have been used for the treatment of metabolic diseases including type 2 diabetes and metabolic syndrome.
Fig.1 Effects of fatty acids (including SC- and LCFAs) derived from the diet by gut microbiota on the regulation of host metabolic and immune functions. (Miyamoto, et al. 2016)
Several FFARs have been identified and used as key components of various physiological processes. Here shows part of fatty acid receptors in humans including FFAR1, FFAR2, FFAR3, FFAR4, which are four variants of the receptor, each encoded by a separate gene (FFAR1, FFAR2, FFAR3, FFAR4). FFARs are categorized according to the chain length of the FFA ligands that activate each FFAR. FFA2 and FFA3 are activated by short-chain FFAs. GPR84 is activated by medium chain FFAs, and FFA1 and GPR120 are activated by medium or long chain FFAs. FFAR2 and FFAR3 may interact to form the FFAR2-FFAR3 receptor heteromer.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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