Prenylation Intrabody Development Service

Creative Biolabs offers the first-rate prenylation Intrabody development platform for our clients all over the world. The prenylation modification on either protein or intrabody is a method to anchor on the intracellular plasma membrane, our professional strategy offers the most suitable searching and optimization in the numerous existing databases and references with various strict tests and validation parameters. Once the most advanced modification strategy emerges, our scientists can work closely to satisfy the specific requirements from our customers, such as a sophisticated cleavage site and high quality of production with superior bioactivity.

Intrabody Development through Prenylation

Prenylation is one of the most critical modifications for a proper physiological function of a natural protein, which is covalently attached to hydrophobic isoprene polymers (branched five-carbon hydrocarbon) at cysteine residues. In the natural bioprocesses, the most common isoprenoid groups are farnesyl (15-carbon) and geranylgeranyl (20-carbon) at cysteine residues via thioether linkages. As a reversible post-translational modification, dynamic prenylation is a determinant for specific protein-protein interactions and particularly critical for eukaryotic cell growth, differentiation, and morphology. Pathological deregulation of prenylation causes multiple diseases such as cancer. Moreover, the geranylgeraniol, farnesol, and dolichol eventually can be cycled to form cholesterol, which is related to many modern diseases. The scientists of Creative Biolabs are diligently learning from the natural prenylation and optimizing it with years’ professional experiences and multiple valid tests.

With decades’ scientific accumulation and extensive experience as a service provider, scientists of Creative Biolabs have collected numerous proteins with prenylation (Ras, Rab, Rho families, lamins, etc.) and found the conserved prenylation motif, which is the most common prenylation site. Our seasoned scientists are able to build up an even better strategy and optimized prenylation based on the conventional natural one to achieve more efficient anchoring with minimized disturbance of normal cell signaling. In terms of our specific platform, our customers will have the most creative and effective prenylation for their project to anchor the desired proteins or intrabodies on the intracellular plasma membrane.

Fig.1 Intracellular plasma membrane-anchored intrabody via prenylation.

Other Anchoring Modification Options provided by Creative Biolabs

Including the intracellular plasma membrane, Creative Biolabs can also develop specific positioning antibody for a variety of destination, which including but not limited to:

To learn more about the development of novel prenylation Intrabody, please feel free to contact us or directly send us an inquiry with your specific demands.

All of our antibody products and services can only be used for preclinical research studies. Do not use them on humans.