NAA and Nephropathy

Nephropathy is a type of kidney disease in which there is gradual loss of kidney function over a period of months to years. Although the causes of nephropathy are diverse, the association between nephropathy and natural-autoantibody (NAA) has been revealed and NAA becomes a sensitive biomarker in the detection and monitoring of nephropathy. As a leading service provider in the field of biological research and antibody development, Creative Biolabs is fully competent in NAA services based on our comprehensive platforms and skilled employees. We are glad to provide global clients with one-stop NAA services and first-class NAA detection kits to meet your goals.

Introduction of Nephropathy

Nephropathy is a broad spectrum of renal diseases or renal damages, which can eventually result in kidney failure. Although initially there are generally no feelings, symptoms may appear later including leg swelling, feeling tired, vomiting, loss of appetite, and confusion. Moreover, complications such as an increased risk of heart disease, high blood pressure, bone disease, and anemia shows that nephropathy may be a potentially fatal condition.

While there are many measures in nephropathy diagnosis including blood tests to measure the estimated glomerular filtration rate (eGFR), urine test to measure albumin, and ultrasound or kidney biopsy to determine the underlying cause, the treatment is often palliative rather than curative.

Nephropathy and NAA

Natural autoantibodies (NAA) are autoreactive antibodies that arise independently of antigenic or mitogenic stimulation and contribute to the stimulation of primitive innate systems. Studies indicated that some NAAs play an important role in the initiation and development of nephropathy. Therefore, NAAs have been regarded as novel biomarkers due to the breadth of their targets ranging from kidney-specific autoantigens to ubiquitous antigens, which reflects the systemic clinical responses to nephropathy and subsequent immunotherapy. Moreover, autoimmune-mediated damage to the kidneys can be triggered by NAAs directed against specific proteins or renal structures. There are two types of well-understanding nephropathy that have been proved with a strong relationship with NAA.

Fig.1 IgA nephropathy pathogenesis. (Knoppova, et al., 2021)Fig.1 An overview of the pathogenesis of IgA nephropathy.1

Creative Biolabs has been long-term devoted to the development of therapeutics antibodies for over a decade, and we are able to provide a range of NAA services. Our group is confident in offering the best and most suitable services to meet your demands for antibody-related services, which are efficient and cost-effectively. Please feel free to contact us for more information and a detailed quote.

Reference

  1. Knoppova, Barbora, et al. "Pathogenesis of IgA nephropathy: current understanding and implications for development of disease-specific treatment." Journal of clinical medicine 10.19 (2021): 4501.

Choosing natural autoantibody (NAA) microarray to profile autoantibody repertoire and reveal novel disease's marker.

For Research Use Only | Not For Clinical Use

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