NAA Services for Anti-laminin Antibody

Equipped with world-leading technology platforms and professional scientific staff, Creative Biolabs is always dedicated to assisting our clients with the most satisfactory research services. Undoubtedly, anti-laminin antibody and other natural autoantibodies (NAA) are comprised within our researches and services. We can provide a full range of anti-laminin marker services for diseases diagnosis and therapeutic monitoring.

Background of Anti-laminin Antibody

Laminin is a group of large heterotrimeric proteins composed of three types of peptide chain: α, β, and γ with different structures and functions. Laminin is the first extracellular matrix glycoproteins detectable in the embryo, which is also a major component of the basement membrane. In structure, cross-shaped laminins are the basis of protein networks in most cells and organs, which lays the foundation for the importance of the basal lamina in influencing cell differentiation, migration, and adhesion.

Various combinations of chains form different laminins and at least 16 distinct laminin isoforms have been identified. Anti-laminins antibodies are a group of corresponding autoantibodies targeting to laminins. Anti-laminins antibodies and abnormality of these laminins are associated with a wide range of human diseases including cancer, infections, heart diseases, and autoimmune disorders.

Fig.1 The molecular structure of laminin. (Vaca, et al., 2020)Fig.1 Structure of the laminin molecule (heterotrimer).1

The Role of Anti-laminin in Myocarditis

Myocarditis is a kind of inflammation of the heart muscle (myocardium), which may cause degeneration or death of heart muscle cells. Myocarditis may be caused by many disorders (e.g. viral infections, bacterial infections, autoimmune disorders, cardiotoxins, drugs) but is often idiopathic. Symptoms can vary and can include fatigue, dyspnea, edema, abnormal heartbeat, breath, chest pain, and sudden death. Diagnosis is often based on symptoms and clinical findings of abnormal ECG, cardiac biomarkers, and cardiac imaging in the absence of cardiovascular risk factors.

It has been widely reported that several circulating autoantibodies induced by infections play a crucial role in the progression and induction of myocarditis. In addition to anti-sarcolemmal antibody and anti-myolemmal antibody, increased circulating anti-laminin antibodies can be observed both in incidence and concentration of myocarditis, perimyocarditis and dilated cardiomyopathy. These high prevalences of anti-laminin antibodies raise the possibility of the diagnostic value to myocarditis.

Choose Creative Biolabs for Your NAA Research and Promote Your Success

In terms of the extensive experience in anti-laminin antibody research, Creative Biolabs has long-term devoted to the investigations of NAA and has accumulated abundant relevant experience in NAA, including anti-laminin antibody. If you are interested in NAA research, just immediately contact us for more detailed information. Our optimized technology and scientific platforms are able to offer the largest and diversiform portfolio of NAA products, related NAA applications and custom services based on the requirements of the clients, which can help you get satisfactory results without large-scale repeated trials.

Reference

  1. Vaca, Diana J., et al. "Interaction with the host: the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria." Medical microbiology and immunology 209.3 (2020): 277-299.
For Research Use Only | Not For Clinical Use

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