NAA Services for Anti-Sarcolemmal Antibody (ASA)

Creative Biolabs is one of the well-recognized experts who are professional in NAA (natural autoantibodies) research with years of experience and high-end technical NAA platforms. Anti-sarcolemmal antibody (ASA) definitely is one of the NAAs we have been researched. Based on our extensive experience and advanced platform, we are proud to offer a full range of anti- ASA biomarker services for our customers all over the world.

Background of Anti-sarcolemmal Antibody (ASA)

Sarcolemmal, also sarcolemma, is the plasma membrane of the muscle cell and is surrounded by a basement membrane and endomysial connective tissue. Sarcolemma, together with an extracellular layer of carbohydrate and collagenous macromolecules which imparts some mechanical strength, is attached to the tendon or aponeurosis of origin and insertion at the end of the fiber. Sarcolemma is similar to the plasmalemma in biochemical composition, which consists of a lipid bilayer and a thin outer coat of polysaccharide material. The function of sarcolemma in muscle cells is generally the same as the plasma membrane in other eukaryote cells. Substantially, the sarcolemma is a kind of excitable membrane, shares many properties with the neuronal cell membrane and play critical actions in various biological activities. Anti-sarcolemmal antibodies (ASAs) are autoantibodies that have been observed and identified in lymphocyte-mediated cytotoxicity.

Fig.1 The skeletal muscle fiber. (https://commons.wikimedia.org/wiki/File:Blausen_0801_SkeletalMuscle.png)Fig.1 The transverse tubules and sarcoplasmic reticulum systems.1

The Role of Anti-sarcolemmal Antibody (ASA) in Myocarditis

Myocarditis is a kind of inflammation and damage of the heart muscle or myocardium with some symptoms, such as an abnormal heartbeat, breath, and chest pain. It has been reported that myocarditis has commonly resulted from viral infections, bacterial infections, autoimmune disorders, and toxins. Several circulating autoantibodies induced by infections have been demonstrated and they may play a crucial role in the progression and induction of myocarditis. Studies reported that ASAs (particularly anti-myolemma antibodies) are identified as a serologic hallmark of inflammatory heart muscle disease and its sequelae. Elevated IgG ASAs derived from the sera show a strong correlation with chronic Chagas myocarditis, which suggested that ASAs might be developed as indicators for myocarditis.

Fig.2 The myocardial sarcolemma function. (Bogdanov, et al., 2021)Fig.2 The role of sarcolemma in the cardiac myocyte.2

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What We Can Do about NAA?

Creative Biolabs has been a long-term expert in the field of antibody development, as well as NAAs, a group of particular antibodies. Equipped with our strong technical and scientific platforms, we are confident in offering various products and services. If you are interested in our services, or you are working on NAA related research, please do not hesitate to contact us for more details.

References

  1. From Wikimedia: By BruceBlaus - Own work, CC BY 3.0, https://commons.wikimedia.org/wiki/File:Blausen_0801_SkeletalMuscle.png
  2. Bogdanov, Vladimir, et al. "Distributed synthesis of sarcolemmal and sarcoplasmic reticulum membrane proteins in cardiac myocytes." Basic Research in Cardiology 116 (2021): 1-16.
For Research Use Only | Not For Clinical Use

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