NAA Services for Anti-Myolemmal Antibody (AMLA)

Creative Biolabs has long-term devoted to the development and application of NAA (natural autoantibodies) research. After years of hard work and construction, we Creative Biolabs has successfully established a globally advanced NAA platform. And now, we are able to provide a full range of anti-myolemmal antibody (AMLA) marker services for diseases diagnosis and therapeutic monitoring. Our professional team is optimized to help you get a milestone development in your NAA project.

Background of Anti-myolemmal Antibody (AMLA)

Myolemmal, also known as myolemma, sometimes is an alias for sarcolemma, which is similar to a typical plasma membrane but has specialized functions for the muscle cell. It is a specialized outer cell membrane surrounding around the muscle fiber cells. Myolemma typically contains an extracellular matrix that consists of several polysaccharides, which ensure the cell to anchor in the tissues to build and support the muscle fibers. It can trigger a very strong fiber with the ability of contraction by connecting to the basement membrane that surrounds all of the connective tissues or other muscle cells. As an anti-cardiac antibody, anti-myolemmal antibody (AMLA) is a cardiocytolytic autoantibody similar to anti-sarcolemmal antibody (ASA), which occurs as a serologic hallmark of heart muscle diseases.

Example for the detection of antimyolemmal antibodies in pericardial fluid from a patient with chronic pericardial effusion by indirect immunofluorescence. Fig.1 Example for the detection of antimyolemmal antibodies in pericardial fluid from a patient with chronic pericardial effusion by indirect immunofluorescence. (Karatolios, 2016)

The Role of Anti-Myolemmal Antibody (AMLA) in Myocarditis

Myocarditis is an inflammation of the heart muscle or myocardium, which can affect your heart muscle and your heart's electrical system, leading to abnormal heartbeat, breath, and chest pain. Viral infections, bacterial infections, autoimmune disorders, and toxins both can elevate the occurrence of myocarditis. Several circulating autoantibodies induced by infections have been demonstrated to play a crucial role in the progression and induction of myocarditis. As one of heart muscle diseases, myocarditis has been described to be associated with both ASAs and AMLAs. High titer of AMLAs antibodies in serum could be observed in patients with dilated cardiomyopathy and chronic pericardial effusion. The detection of AMLAs antibodies, particular homologous AMLAs of IgM type, might be beneficial to help the diagnosis and prediction of myocarditis.

Choose us for Your NAA Projects

We can provide comprehensive NAA services, from NAA detection, NAA profiling, to NAA epitope mapping aided by our well-established platforms and experienced scientists. Creative Biolabs is capable to provide the largest and diversiform portfolio of NAA products and services about NAA. We also provide custom services based on the requirements of the clients to meet the specific demand. Just contact us and communicate with us about your needs. Our proven and optimized platforms can help you quickly get satisfactory results without repeated trials.

Reference:

  1. Karatolios, K.; et al. Anticardiac Antibodies in Patients with Chronic Pericardial Effusion. Disease markers. 2016, 2016(3): 1-4.
For Research Use Only | Not For Clinical Use

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