Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsProstaglandins are lipid-derived autacoids that modulate many physiological systems including the CNS, cardiovascular, gastrointestinal, genitourinary, endocrine, respiratory, and immune systems. The physiological effects of prostaglandins are mediated in part by G-protein-coupled prostanoid receptors, a family of rhodopsin-like seven transmembrane spanning receptors (GPCRs). The prostanoid receptor subfamily is comprised of eight members (DP, EP1–4, FP, IP, and TP), which are classified according to the prostanoid ligand that each binds with the greatest affinity. Different prostanoid receptor isoforms show similar ligand binding but differ in their signaling pathways, their sensitivity to agonist-induced desensitization, and their tendency towards constitutive activity. The IP, DP, EP2, and EP4 receptors are relaxant receptors that induce smooth muscle relaxation, while the TP, FP, and EP1 receptors are contractile receptors that cause smooth muscle contraction. The remaining receptor, EP3, is an inhibitory receptor. These receptors have played diverse roles in the physiologic and pathologic setting.
Different agonists and antagonists targeting each of these receptors have been developed. Here, we give an introduction of the human prostaglandin receptors regarding their signaling pathways, pharmacology, and their roles in human diseases.
To help investigate the function and structure of these membrane receptors, Creative Biolabs now utilizes different strategies and systems that allow the protein targets to be reconstituted into detergent micelles, or more native-like lipid environments, such as proteoliposomes and nanodiscs. Moreover, we employ a virus-like particle technology to collect enriched membrane proteins in lipoparticles. Additionally, polymers are used to isolate and solubilize membrane proteins from cellular membranes without the need of detergents, which maximally preserves the functional and structural integrity.
Meanwhile, our Magic™ membrane protein antibody discovery platform is also introduced to help the discovery and development of antibodies against these protein targets. We have accumulated invaluable expertise and experience in working with different clients and projects. We also present DNA immunization service for anti-membrane protein antibody development. For further information or a quote, please contact us today.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
