Creative Biolabs is proud to introduce our iPSC-facilitated tyrosinase expression assay to our esteemed clients. We urgently hope to contribute to the success of your projects on pigmentation.
Tyrosinase (also known as TYR, ATN, SHEP3, etc.), is the rate-limiting enzyme in the whole pathway of melanin production, primarily distributed in melanosomes of the melanocytes.
Tyrosinase is a copper-containing oxidase, which widely exists in animal, plant, and fungal species, activating the production of melanin and other pigments from tyrosine by oxidation. The expression level of tyrosinase is regulated by the upstream modulator microphthalmia-associated transcription factor (MITF), thus participating in multiple downstream pathways.
Fig.1 Possible tyrosinase signaling pathways in melanocytes.1
In humans, melanin is the key enzyme of pigmentation in skin, eyes, and hair, protecting the tissues from damage caused by UV radiation. Its expression level and activity are directly associated with the synthesis of melanin. However, when the expression of tyrosinase is abnormally elevated, it induces hyperpigmentation disorders and raises risks of melanomas.
Considering the critical role in melanogenesis, tyrosinase has emerged as a hotspot for research and clinical projects, especially for skin diseases, as well as for commercial purposes in the cosmetic industry. Especially, inhibiting tyrosinase has emerged as one of the most attractive therapeutic strategies to deal with excessive pigmentation, and has inspired many related studies and trials. Accordingly, tyrosinase expression assay has become a requisite tool in those studies on pigmentation to evaluate the reaction of tyrosinase levels.
Induced pluripotent stem cells (iPSCs) have been regarded as an optimal source of melanocytes and have played various roles in studies on pigmentation for clinical, research, or commercial purposes. At Creative Biolabs, we provide iPSC-facilitated tyrosinase expression assay service here with multiple methods to choose from, to meet your specific requirements for the analysis of tyrosinase expression, including but not limited to RNA-seq, qRT-PCR, Dual-luciferase, WB blot, and other available experiments. We offer meticulous and customized experiment design, standardized operation, reliable data analysis, and detailed reports, to assist you in your exploration of the melanogenesis pathway.
Creative Biolabs is dedicated to offering our optimized iPSC-facilitated tyrosinase expression assay services for our global clients to aid in your research on pigmentation. With cutting edge technical platforms and a professional team of scientists, we are pleased to offer our state-of-art products and services. If you want to learn more about detailed information, please feel free to contact us at any time.
Reference
For Research Use Only. Not For Clinical Use.
