Internalization Enhancement Services

The internalization capacity of therapeutic antibodies has become one of preferable properties in cancer immunotherapies. Cancer development is a complicated process that involves the abnormal expression and regulation of an intricate network of genes. Recent progress focuses on cancer surface receptors due to their relatively easy accessibility and as a result, many of the cancer cell surface receptors have been developed as targets for immunotherapies. However, with the accumulative knowledge of cancer genesis, formation, progression, and metastasis, it is becoming more and more clear that many cytoplasmic molecules are also crucial for cancer biology. Targeting those intracellular targets contributes to the development of a new breed of immunotherapeutic agents that will help with the crusade against cancer.

In terms of extensive experience in antibody engineering and modification, Creative Biolabs can offer a series of specific services to enhance the internalization capacity of discovered transbodies.

Internalization Through Enhanced Receptor Binding Affinity

Creative Biolabs can utilize affinity maturation approach to enhance the internalization capacity of transbodies.

Internalization Enhancement by Antibody Modifications

Creative Biolabs offers a series of antibody modification services to facilitate antibody internalization and targeting of intracellular targets.

Internalization Enhancement by Antibody Cationization

Creative Biolabs has developed a series of intracellular delivery pathways based on the cationization process.

Platform:

Intracellular Antibody Development Platform

All of our antibody products and services can only be used for preclinical research studies. Do not use them on humans.