NAA Services for Anti-La Autoantibodies

With years of experience in NAA (natural autoantibodies) research, Creative Biolabs has established a powerful platform that is optimal for NAA detection, NAA profiling, and NAA epitope mapping, etc. We can provide a full range of anti-La autoantibodies services with high quality and competitive price for global customers. Our services may contribute to disease diagnosis and therapeutic monitoring.

Background of Anti-La Autoantibodies

Anti-La antibodies are the autoantibodies that target 47-kDa La antigen. La antigen is combined transiently with precursors of the small RNAs synthesized by RNA polymerase III, including Y RNA, thus protecting them from exonucleases. La is a termination factor for RNA polymerase III. It is located in the nucleus and cytoplasm of mammalian cells. Anti-La autoantibodies frequently occur in sera with anti-Ro autoantibodies. They represent important serologic markers of Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE).

The Role of Anti-La Autoantibodies in SLE

Autoantibodies to the La antigen are detected in approximately 15% of SLE patients. The 5-15% of patients with SLE having anti-La autoantibodies usually are those with associated SS and seldom with severe kidney involvement. Anti-La autoantibody levels do not correlate with disease activity. 25-40% of patients with subacute cutaneous lupus are Ro and La autoantibodies positive. Autoantibodies to the La antigen are rarely found in normal individuals. Hence, anti-La autoantibodies are regarded as markers of SLE and anti-La autoantibody test may help to diagnose SLE.

Fig.1 A comprehensive view of autoantigens targeted by autoantibody in SLE, SS, and other diseases. (Didier, et al., 2018)Fig.1 A comprehensive view of autoantigens targeted by autoantibody in SLE, SS, and other diseases.1

The Role of Anti-La Autoantibodies in SS

Autoantibodies to the La antigen are also detected in patients with SS, the second most common disorder among the group of chronic systemic rheumatic diseases. Anti-La autoantibodies are found in 25-80% of patients with primary SS, particularly those with hypergammaglobulinemia, and extra-glandular manifestations. 20-90% of patients with secondary SS have anti-La autoantibodies. Usually, the presence of anti-La autoantibodies is always associated with the presence of anti-Ro autoantibodies. It is uncommon that patients with SS have no anti-La autoantibodies. Moreover, anti-Ro and anti-La autoantibodies have been identified previously in the saliva, serum and tear fluid of SS patients. Measurement of tear fluid or saliva or serum levels of anti-Ro/SSA and anti-La/SSB autoantibodies may serve as a valuable diagnostic indicator of SS.

Antibodies to Ro, La, SP1, CA6, and PSP were determined by ELISA in the sera of patients with idiopathic dry eyes and dry mouth with Schirmer’s tests < 3 mm (9 patients), Schirmer’s tests < 6 mm (10 patients). Fig.2 Antibodies to Ro, La, SP1, CA6, and PSP were determined by ELISA in the sera of patients with idiopathic dry eyes and dry mouth with Schirmer's tests < 3 mm (9 patients), Schirmer's tests < 6 mm (10 patients). (Everett, 2017)

What We Can Do about NAA?

Based on our well-established platforms, Creative Biolabs is able to provide a full range of NAA services for global clients. Our scientists also offer comprehensive technical guidance thereby avoiding unnecessary detours and accelerating project progress. Our NAA services include:

If you can't find your interested services in our NAA service list, please tell us your requirement. We could provide custom service for you to meet the special requirement of your project.

Features of Our Services

Equipped with advanced technologies and the best expert team, Creative Biolabs is very confident to provide high-quality and low-cost NAA products and services for global clients. We believe that our service will make your project achieve twice the result with half the effort. If you are interested in the NAA service, please don't hesitate to contact us for more information.

References:

  1. Didier, Kevin, et al. "Autoantibodies associated with connective tissue diseases: what meaning for clinicians?." Frontiers in immunology 9 (2018): 541.
  2. Everett, Sandra, et al. "Analysis of novel Sjogren's syndrome autoantibodies in patients with dry eyes." BMC ophthalmology 17.1 (2017): 1-6.
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