NAA Services for Anti-Ro Autoantibodies

The elevated value of NAA (natural autoantibodies) has been implicated in the association with the diagnosis of autoimmune disease. Equipped with extensive experience, advanced platform and professional technical team in the field of NAA research, Creative Biolabs has become a world-leading service provider by offering a full range of NAA services with high quality and affordable price for global customers. We can provide a series of NAA service to help you discover new disease targets and improve treatment efficiency.

Background of Anti-Ro Autoantibodies

Anti-Ro antibodies are autoantibodies that target one or both of two cellular proteins with molecular weights of about 60 kD and 52 kD, called Ro60 and Ro52, respectively. Ro60 can bind misfolded RNA and exert a role in quality control of U2 and 5S ribosomal RNA. Like the Sm core particle, Ro60 antigen forms a circular structure. Mice lacking Ro60 have been shown to develop a lupus-like syndrome, thus suggesting that Ro60 may be involved in preventing systemic autoimmune disease. Ro52 is not an integral component of the Y1 to Y5 RNPs. It is a member of the interferon-inducible TRIM family. The protein is located in the cytoplasm and acts as an E3 ubiquitin ligase. Anti-Ro autoantibodies are firstly originally identified in patients with Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE).

Fig.1 Immunofluorescence pattern of Ro and La antibodies. (https://commons.wikimedia.org/wiki/File:SSA_SSB_ANA.jpg)Fig.1 Immunofluorescence pattern of Ro and La antibodies.1

The Role of Anti-Ro Autoantibodies in SLE

The presence of anti-Ro autoantibodies is associated with the diagnosis of SLE. Elevated anti-Ro autoantibody levels have been shown in 40-50% SLE cases. Patients with SLE have been found to have different types of anti-Ro responses. Some people have autoantibodies targeting both the 52 kD and 60 kD proteins, while others have antibodies targeting only one of them. Anti-Ro autoantibody detection has diagnostic value for some of the clinical subsets of SLE, including subacute cutaneous lupus erythematosus, homozygous C2 and C4 deficiency, neonatal lupus erythematosus, and ANA-negative lupus.

Fig.2 The roles of Ro52/TRIM21 in SLE and primary SS. (Hsu and Yung-Luen, 2023)Fig.2 The roles of Ro52/TRIM21 in SLE and primary SS.2

The Role of Anti-Ro Autoantibodies in SS

Anti-Ro antibodies are the hallmark autoantibodies in SS, a systemic chronic inflammatory disorder characterized by lymphocytic infiltrates in exocrine organs. They are found in approximately 50% patients with SS, 75% patients with primary SS and 15% patients with secondary SS. Moreover, these antibodies are associated with earlier disease onset, glandular dysfunction, and extraglandular manifestations as well as with other B cells activation markers. However, the presence of anti-Ro autoantibodies cannot by itself be used to establish a diagnosis of SS because antibodies against Ro are sometimes found in healthy individuals. They can be used as reference indexes.

What We Can Do about NAA?

Autoimmune diseases are caused by a person's immune system fails to distinguish between "self" and "non-self". The redundant NAAs are produced and mistakenly target and react with a person's own tissues or organs. This suggests a possible role of NAA in the pathological process of autoimmune diseases. Hence, it is necessary to carry out NAA-related research, which is helpful for the diagnosis and prognosis of autoimmune diseases. Based on our powerful platform, our experts with extensive experience can help you design the best protocol for NAA research. We also provide a comprehensive full series of NAA services including but not limited to:

Features of Our Services

Creative Biolabs has established a powerful NAA analytical platform which is applied for NAA detection and profiling. Besides, professional scientists also can help our clients to design the optimal protocol and attain their interested experimental data to meet their special requirements. If you are interested in our NAA service, please feel free to contact us for more details.

Reference:

  1. From Wikipedia: By Simon Caulton - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/wiki/File:SSA_SSB_ANA.jpg
  2. Hsu, Chueh-Hsuan, and Yung-Luen Yu. "The interconnected roles of TRIM21/Ro52 in systemic lupus erythematosus, primary Sjögren's syndrome, cancers, and cancer metabolism." Cancer Cell International 23.1 (2023): 289.
For Research Use Only | Not For Clinical Use

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