Anti-CTLA4 aptamer(Cat#: CTApt-2047)
This product is an aptamer which binds to the CTLA4 with an affinity of <100 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
CTLA4 |
| Alternative Names |
Cytotoxic T-Lymphocyte Associated Protein 4; CTLA-4; CD152; Insulin-Dependent Diabetes Mellitus 1 ; Cytotoxic T-Lymphocyte Protein 4; Celiac Disease 3 ; GSE; CD ; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4 ; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; Cytotoxic T-Lymphocyte-Associated Antigen 4; CD152 Antigen ; CELIAC3 ; IDDM12 ; ALPS5 ; CTLA4 ; GRD4 |
| Gene ID |
1493 |
| UniProt ID |
P16410 |
| Target Overview |
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. |
| Chemical Modification |
2'F-RNA |
| Length |
20-40 nt |
| Affinity (Kd) |
<100 nM |
| Binding Conditions/Buffer |
20mM HEPES pH 7.4, 0.15M NaCl, 2mM CaCl2; 0.01% BSA |
| GC Content |
0.69 |
| Molecular Weight |
10998.1 |
| nmoles/OD260 |
2.41 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
