Overview Workflows Applications Related Products Featured Services Q&A Resources
Creative Biolabs offers high-quality, customized functional assays for complement C5 convertase, leveraging advanced technologies and extensive scientific experience to assist clients in the advancement of complement-based therapies.
Overview of Complement C5 Convertase
C5 convertase is an enzyme within the serine protease family, crucial to innate immunity, and operates in the complement system to ultimately lead to cell lysis. There are four distinct C5 convertases capable of cleaving the protein C5 into the fragments C5a and C5b. Two of these convertases function as physiological complement enzymes, associate with the cell membrane, and activate either the classical or the alternative pathway of the complement system.
Fig. 1 Complement C5 convertase participates in complement activation steps.Distributed under CC BY-SA 4.0, from Wiki, without modification.
Complement C5 Convertase Functional Assay Introduction
Method
The complement C5 Convertase functional assay is a laboratory procedure designed to evaluate the activity and performance of the C5 Convertase component within the complement system across various samples, including human serum, plasma, tissue homogenates, cell lysates, and cell culture supernatants. This assessment can be conducted using hemolytic assays and enzyme-linked immunosorbent assays (ELISA).
Analysis
In the realm of complement studies, as all pathways intersect at the convertase phase, one of the pivotal functional evaluations involves assessing convertase activities and understanding how specific components affect them. By conducting functional or activity assays of C5 Convertase, we can evaluate and scrutinize its function at the quantification level.
Workflow of Complement C5 Convertase Functional Test
Application
Exploring the functional dynamics of C5 convertase enzymes is essential for unveiling the molecular mechanisms driving the dysregulation and hyperactivity of convertases in human diseases. This knowledge is critical for crafting future therapeutic strategies to counteract undesirable complement activation during systemic infections and acute inflammation. The C5 convertase functional assay paves the way for tailoring anti-complement therapies, thus advancing disease treatment.
Related Products
Featured Services
|
|
|
Total Complement Activity Test
|
Complement Activation Products Test
|
|
Creative Biolabs offers total complement activity test services for our clients. Total complement activity tests include CH50, AH50, and LP50.
|
Pathologically elevated complement activation can be accurately assessed through complement activation product tests facilitated by monoclonal antibodies targeting activation-specific neoepitopes.
|
|
Learn more
|
Learn more
|
Questions & Answer
A: Thanks for asking! C5 convertase functional assays are critical tools in understanding how the complement system operates, especially in diseases caused by overactive immune responses. At Creative Biolabs, we offer high-quality, customized assays using cutting-edge technologies to evaluate enzyme activity precisely.
A: Absolutely. Our C5 convertase functional assays are designed to provide detailed insights into enzyme activity and regulation, which are essential for advancing complement-based therapies. Leveraging our extensive expertise and customized solutions, we are poised to support your research objectives. Reach out now to get started!
A: Thank you for contacting us! We specialize in analyzing a diverse array of samples, such as human plasma, serum, cell lysates, culture supernatants, tissue homogenates, etc. Our adaptable methodology guarantees precise results tailored to your specific research needs.
A: Our assays employ advanced methods like hemolytic tests and ELISA to assess C5 convertase activity across various pathways in the complement system. This helps evaluate enzyme function and its role in diseases.
A: Thank you for asking! Yes, our functional assays provide critical insights into the molecular mechanisms of complement deregulation, a key factor in inflammatory and infectious diseases. These insights can facilitate the development of therapeutic strategies. Let us work together to propel your research forward.
Resources
Creative Biolabs is dedicated to delivering optimal and practical complement-related services, built upon a dependable and standardized complement assay platform. We provide tailored complement C5 convertase functional assays for the rapid assessment of complement activity.
We invite you to reach out to us to discuss your interests or inquiries regarding the complement function assay.
For Research Use Only.
Related Sections:
