This product is an aptamer which binds to the Receptor Tyrosine Kinase (RET) Mutant with an affinity of <50 nM.
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| Target Category | Protein |
| Target | Receptor Tyrosine Kinase (RET) Mutant |
| Chemical Modification | 2'-F-RNA |
| Length | 40-60 nt |
| Affinity (Kd) | <50 nM |
| Binding Conditions/Buffer | Selection buffer: RPMI 1640 |
| GC Content | 54% |
| Molecular Weight | 16281.84 g/mole |
| Extinction Coefficient | 511900 L/(mole·cm) |
| nmoles/OD260 | 1.95 |
Outstanding aptamersExcellentOverall, it is an excellent aptamer for detecting receptor tyrosine kinase expression in cells.
Good aptamer for detection of RET activityExcellentOne of the few aptamers that can be used to truly assess RET activity. I think it should be widely used by scientists.
I can obtain repeatable resultsExcellentI was looking for RET positive cells in my project and this aptamer gave consistent results every time.