Anti-TWIST1 Aptamer SELEX Service(Cat#: CTApt-848)
This is an aptamer development services to screening aptamers binds to the TWIST1 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
TWIST1 |
| Alternative Names |
Twist Family BHLH Transcription Factor 1; BHLHa38; H-Twist; Twist Basic Helix-Loop-Helix Transcription Factor 1; Class A Basic Helix-Loop-Helix Protein 38; Twist-Related Protein 1; BPES2; TWIST; CRS1; SCS; Blepharophimosis, Epicanthus Inversus And Ptosis 3; Twist Homolog 1 (Drosophila); TWIST Homolog Of Drosophila; B-HLH DNA Binding Protein; Saethre-Chotzen Syndrome; Acrocephalosyndactyly 3; Craniosynostosis; Twist Homolog 1; BHLHA38; TWIST1; BPES3; SWCOS; ACS3; CRS; CSO |
| Gene ID |
7291 |
| UniProt ID |
Q15672 |
| Target Overview |
This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
