Biotin-Liposome (PEGylated) is Liposome (PEGylated) with the biotin group. Biotinylated liposomes can be conjugated noncovalently with streptavidin through either direct interaction with the protein/antibody conjugated to streptavidin or by coupling with other biotinylated proteins using streptavidin as a bridging molecule. Both avidin and streptavidin form strong noncovalent bond with biotin.
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What is Biotin-Liposome (PEGylated)?
It is a PEGylated liposome with a biotin group designed for noncovalent conjugation with (strept)avidin.
What are potential challenges when using this product?
Ensuring a high ratio of (strept)avidin to biotin-liposomes to prevent lipid precipitation and achieving efficient conjugation.
Can Biotin-Liposome (PEGylated) be used for in vivo studies?
They are primarily designed for research use and should be validated for specific in vivo applications.
What is the main advantage of PEGylation in these liposomes?
Increased circulation time and reduced clearance by the immune system.
Blood glucose levels in rats after administration of insulin solution and insulin liposomes.
This study explored the potential of biotin liposomes (BLPs) as oral delivery carriers for insulin. Researchers incorporated biotin-DSPE into the lipid bilayer to obtain BLPs. They then investigated the hypoglycemic effects of orally administered BLPs in normal rats. The results demonstrated that BLPs significantly enhanced the hypoglycemic effect of insulin compared to unmodified liposomes. In this research, biotin liposomes serve as a delivery system that improves the bioavailability and effectiveness of insulin.
Zhang, Xingwang, et al. "Enhanced hypoglycemic effect of biotin-modified liposomes loading insulin: effect of formulation variables, intracellular trafficking, and cytotoxicity." Nanoscale Research Letters 9 (2014): 1-10.
Distributed under Open Access license CC BY 2.0, without modification.
Excellent Stability
The stability of these liposomes under experimental conditions is remarkable.
High Conjugation Efficiency
Achieved high coupling efficiencies with our biotinylated proteins using these liposomes.
Improved Circulation Time
PEGylation has markedly improved the circulation time of our formulations.
High-Quality Liposomes
These liposomes' high quality is evident in every aspect of our experimental usage.
Enhanced Targeting Specificity
Targeting has been significantly enhanced, facilitating more accurate experimental outcomes.
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