Cyanur-Liposome (PEGylated) is Liposome (PEGylated) with the cyanur group. Proteins can be covalently coupled to the liposomes via amine-reactive cyanur-groups, either directly to the vesicle surface using cyanuric chloride-activated DSPE (cyanur-DSPE) or to the distal ends of PEG-spacers using activated cyanur-PEG-PE (ammonium salt). Cyanuric chloride at the PEG terminus functions to link peptides, antibodies and other amine-containing biomolecules or nanoparticles via a nucleophilic substitution reaction under basic conditions. Antibodies or other proteins can be conjugated without any previous derivatization.
Cyanur-Liposome (PEGylated) is a PEGylated liposome with a cyanur group allowing for covalent conjugation to proteins via amine-reactive cyanur groups.
What is the recommended pH condition for conjugation?
The conjugation should be done under mild basic conditions, specifically at pH 8.8 using borate buffer.
Are these liposomes suitable for in vivo studies?
Yes, due to their PEGylation, these liposomes are suitable for in vivo studies, providing improved circulation times and reduced immunogenicity.
How do Cyanur-Liposomes (PEGylated) compare with traditional liposomes for drug delivery?
They offer enhanced stability, better circulation times, and efficient protein conjugation, making them superior for targeted drug delivery applications.
Are there any known limitations of using these liposomes?
Some random attachments can occur due to the reactivity of cyanuric chloride, potentially affecting binding affinity.
Enhanced Drug Delivery Efficiency
The cyanur group on Cyanur-Liposome (PEGylated) has streamlined our drug delivery research, allowing for efficient and stable protein conjugation.
User-Friendly Protocol
The instructions for conjugating proteins were straightforward, making the entire process user-friendly and efficient.
Enhanced Circulation Time
The PEGylation significantly enhanced the circulation time of the liposomes in our animal models.
Ideal for In Vivo Studies
These liposomes proved ideal for our in vivo studies, maintaining stability and functionality throughout.
Excellent Customer Support
Creative Biolabs provided excellent customer support, guiding us through the conjugation process.
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