Succinyl-Liposome is Liposome with the carboxyl group, which can be activated by EDC (1-ethyl-3-[3-dimethylaminopropyl] carbodiimide) and react with sulfo-NHS (N-hydroxysulfosuccinimide) to produce a significantly more stable and more soluble active intermediate (NHS ester). The intermediate can covalently conjugate to the amine group on the proteins, peptides or antibodies through displacement of sulfo-NHS group by amine.
Lipid Composition
L-alpha-Phosphatidylcholine, Cholesterol, 18:1 Succinyl PE
What are the key characteristics of succinyl liposomes?
Succinyl liposomes are specialized liposomes that have carboxyl groups incorporated into their structure. This modification allows them to be activated by EDC for the creation of stable and soluble species-reactive intermediates, making them ideal for conjugation with amines on proteins, peptides, or antibodies.
How can succinyl liposomes be utilized in targeted drug delivery systems?
Succinyl liposomes are designed for targeted drug delivery, exploiting their carboxyl functional groups for conjugation with targeting ligands, imaging agents, or therapeutic molecules. This modification enhances their capability to deliver drugs specifically to target sites within the body.
What is the preferred protocol for conjugating peptides or proteins to succinyl liposomes?
To conjugate peptides or proteins to succinyl liposomes, it is recommended to dissolve the biomolecule in an amine-free and carboxylate-free buffer, then add it to activated liposomes maintaining a 10:1 molar ratio of lipid to biomolecule. After a 2-hour reaction at room temperature, non-conjugated peptides or proteins should be removed by dialysis to ensure purity and stability of the liposome conjugates.
What are some potential applications of succinyl liposomes in research?
Due to their chemical properties, succinyl liposomes are extensively used in research for the delivery of bioactive molecules including drugs, peptides, and nucleic acids. These liposomes are particularly beneficial in studies requiring precise delivery mechanisms to enhance therapeutic efficacy while minimizing systemic side effects.
How does the physical and chemical stability of succinyl liposomes impact their use in clinical research?
The incorporation of succinyl groups into liposomes enhances both their physical and chemical stability. This makes succinyl liposomes suitable for complex biochemical applications, including those in clinical research where stability is crucial for reliable results.
Advanced Formulation for Enhanced Binding
Creative Biolabs' succinyl-liposome products provide enhanced binding capabilities for targeted therapies, making them integral to our drug delivery system research.
Creative Biolabs' Precision Drug Delivery
Creative Biolabs has perfected the use of succinyl-liposomes to facilitate precise drug delivery, crucial for our targeted treatment studies.
Enhanced Reactivity for Conjugation
These liposomes show enhanced reactivity for conjugation, improving the efficacy of our bioconjugation processes.
Optimal for Complex Therapeutic Agents
The succinyl-liposomes from Creative Biolabs are optimal for delivering complex therapeutic agents, providing consistent results across our research.
High-Quality and Customizable Formulations
The high-quality and customizable nature of these succinyl-liposomes makes them a preferred choice for our specialized pharmaceutical applications.
Click the button below to contact us or submit your feedback about this product.