NAA Services for Anti-Synapsin I Antibodies

Creative Biolabs is a leading service provider in the natural autoantibody (NAA) field. We can provide custom-specific raw materials of immunodiagnostic kits and high-quality service for NAA detection and analysis. At present, we are capable to provide a full range of anti-synapsin I antibody profiling services. Our customized development services and solutions are tailored to meet our customers’ unique specifications.

Background of Anti-synapsin I Antibodies

The synapsins are a family of proteins associated with the regulation of neurotransmitter release at synapses. Specifically, they are thought to play a critical role in regulating the number of synaptic vesicles available for release via exocytosis at any time. Synapsins exist in invertebrates and vertebrates and are somewhat homologous across evaluated vertebrates. Humans and most other vertebrates have three genes encoding three different synapsin proteins. Anti-synapsin I antibodies are a type of natural autoantibodies that bind to the synapsin I if the autoimmune disorders happen in the body. Evidence indicated that the anti-gliadin antibodies from patients with celiac disease also bound to the synapsin I protein. In addition, autoantibodies to human synapsin Ia and Ib are detectable in a proportion of patients with different psychiatric and neurological disorders.

Fig.1 Synapsin domain structure and tetrameric structure of synapsins. (Zhang and George, 2021)Fig.1 Synapsin domain structure and tetrameric structure of synapsins.1

The Role of Anti-synapsin I Antibodies in Celiac Disease

Celiac disease (CD) is an inflammatory disorder, commonly caused by an improper immune response to ingested wheat gluten (gliadin and glutenin) and related cereal proteins in genetically susceptible individuals. CD may lead to villous atrophy, crypt hyperplasia and lymphocytic infiltration in the small intestine. CD is also associated with various extraintestinal syndromes, including neurologic complications such as neuropathy, ataxia, seizures, and neurobehavioral changes. Previous study showed that the anti-gliadin Abs from patients with CD also bound to the synapsin I protein. The anti-synapsin autoantibody reactivity was found in many patients with CD, whereas it was absent in control subjects without anti-gliadin Abs. Therefore, it is possible that the anti-gliadin Ab response would affect synapsin I activity in some patients with gluten sensitivity, thus further disturbing neurotransmitter release and resulting in neurologic dysfunction. The immune cross-reactivity may also cause tissue damage through T cell-mediated mechanisms.

Fig.2 The link between CD and autism spectrum disorder pathogenesis: interference with neurotransmission. (Di, et al., 2020)ig.2 The link between CD and autism spectrum disorder pathogenesis: interference with neurotransmission.2

What We Can Do about NAA?

Aided by our state-of-the-art technology platforms and prominent scientists, we can offer high-quality NAA services to cover every step of your program, including NAA detection and profiling, NAA affinity measurement, NAA epitope mapping, and paratope mapping. A wide range of NAA products is available for your choice.

Why Choose Us?

Creative Biolabs has been dedicated to leveraging our cutting-edge technologies and expertise to facilitate all kinds of custom projects. We are more than happy to provide professional assistance of NAA services for anti-synapsin I antibodies to worldwide clients. We also provide NAA detection and profiling service to benefit disease diagnosis that you may be interested in. Please feel free to contact us for more information.

References:

  1. Zhang, Minchuan, and George J. Augustine. "Synapsins and the synaptic vesicle reserve pool: floats or anchors?." Cells 10.3 (2021): 658.
  2. Di Liberto, Diana, et al. "Brain opioid activity and oxidative injury: Different molecular scenarios connecting celiac disease and autistic spectrum disorder." Brain Sciences 10.7 (2020): 437.
For Research Use Only | Not For Clinical Use

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